Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Functionalized Magnetic Nanoparticles for the Separation and Purification of Proteins and Peptides Publisher



Eivazzadehkeihan R1 ; Bahreinizad H2 ; Amiri Z1 ; Aliabadi HAM3 ; Salimibani M4 ; Nakisa A5 ; Davoodi F6 ; Tahmasebi B7 ; Ahmadpour F1 ; Radinekiyan F1 ; Maleki A1 ; Hamblin MR8, 9, 10 ; Mahdavi M11 ; Madanchi H12, 13
Authors
Show Affiliations
Authors Affiliations
  1. 1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  2. 2. Mechanical Engineering Department, Sahand University of Technology, Tabriz, Iran
  3. 3. Protein Chemistry Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  4. 4. School of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran
  5. 5. Organic Chemistry Laboratory, Department of Chemistry, Tarbiat Modares University, Tehran, 14155-4838, Iran
  6. 6. Pharmaceutical and Heterocyclic Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  7. 7. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  8. 8. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 02114, MA, United States
  9. 9. Department of Dermatology, Harvard Medical School, Boston, 02115, MA, United States
  10. 10. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa
  11. 11. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Department of Biotechnology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  13. 13. Drug Design and Bioinformatics Unit, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

Source: TrAC - Trends in Analytical Chemistry Published:2021


Abstract

Nanoparticles have been widely employed for different biomedical applications due to their remarkable chemical and physical properties. The surface of nanomaterials can be modified by functionalization to create a strong recognition and binding sites between biological macromolecules and the nanostructures. Scientists have used this fact in the purification and extraction of bio-macromolecules like proteins, especially using magnetic nanoparticles that can be manipulated by an external magnetic field. The functionalization agents have included synthetic and natural polymers, antibodies, biomolecules or zwitterionic materials, as well as different nanomaterials such as carbon-based nanomaterials and metal oxide nanoparticles. The binding with the target is directly influenced by the size, surface energy and charge of the particles. Hydrophobicity and hydrophilicity of the nanoparticles is another important consideration that affects the selective purification of proteins by decorated magnetic nanoparticles. © 2021 Elsevier B.V.
Related Docs
View other Related Docs
1. Design and Synthesis of a Novel Nanocomposite Based on Magnetic Dopamine Nanoparticles for Purification of Α-Amylase From the Bovine Milk, Scientific Reports (2021)
2. Pectin-Cellulose Hydrogel, Silk Fibroin and Magnesium Hydroxide Nanoparticles Hybrid Nanocomposites for Biomedical Applications, International Journal of Biological Macromolecules (2021)
3. A Novel, Bioactive and Antibacterial Scaffold Based on Functionalized Graphene Oxide With Lignin, Silk Fibroin and Zno Nanoparticles, Scientific Reports (2022)
4. Review: The Latest Advances in Biomedical Applications of Chitosan Hydrogel As a Powerful Natural Structure With Eye-Catching Biological Properties, Journal of Materials Science (2022)
5. Palladium-Coated Thiourea Core-Shell Nanocomposite As a New, Efficient, and Magnetic Responsive Nanocatalyst for the Suzuki-Miyaura Coupling Reactions, Materials Research Express (2021)
6. Magnetic Copper Ferrite Nanoparticles Functionalized by Aromatic Polyamide Chains for Hyperthermia Applications, Langmuir (2021)
7. Biocompatibility and Antimicrobial Investigation of Agar-Tannic Acid Hydrogel Reinforced With Silk Fibroin and Zinc Manganese Oxide Magnetic Microparticles, Journal of Inorganic and Organometallic Polymers and Materials (2022)
8. Magnetized Chitosan Hydrogel and Silk Fibroin, Reinforced With Pva: A Novel Nanobiocomposite for Biomedical and Hyperthermia Applications, RSC Advances (2023)
Experts (# of related papers)
View all Related Experts
Mohammad Mahdavi (28)
Fatemeh Atyabi (3)
Other Related Docs
9. Synthesis and Characterization of Cellulose, Β-Cyclodextrin, Silk Fibroin-Based Hydrogel Containing Copper-Doped Cobalt Ferrite Nanospheres and Exploration of Its Biocompatibility, Journal of Nanostructure in Chemistry (2023)
10. Functionalized Graphene Oxide Nanosheets With Folic Acid and Silk Fibroin As a Novel Nanobiocomposite for Biomedical Applications, Scientific Reports (2022)
11. Magnetic Chitosan-Silk Fibroin Hydrogel/Graphene Oxide Nanobiocomposite for Biological and Hyperthermia Applications, Carbohydrate Polymers (2023)
12. Applications of Carbon-Based Conductive Nanomaterials in Biosensors, Chemical Engineering Journal (2022)
13. Novel Magnetic Organic–Inorganic Hybrids Based on Aromatic Polyamides and Znfe2o4 Nanoparticles With Biological Activity, Scientific Reports (2021)
14. Functionalization of Zinc Ferrites Nanoparticles by Cyclic Aromatic Polyimide Chains As a Novel Star Polymer With Antibacterial Activity and Low Toxicity, Journal of Industrial and Engineering Chemistry (2024)
15. Functionalization of Chitosan by Metformin, Nickel Metal Ions and Magnetic Nanoparticles As a Nanobiocomposite for Purification of Alkaline Phosphatase From Hen's Egg Yolk, Journal of Chromatography A (2022)
16. Nickel-Salen Supported Paramagnetic Nanoparticles for 6-His-Target Recombinant Protein Affinity Purification, Journal of Chromatography A (2017)
17. Hyperthermia and Biological Investigation of a Novel Magnetic Nanobiocomposite Based on Acacia Gum-Silk Fibroin Hydrogel Embedded With Poly Vinyl Alcohol, Heliyon (2024)
18. Hybrid Bionanocomposite Containing Magnesium Hydroxide Nanoparticles Embedded in a Carboxymethyl Cellulose Hydrogel Plus Silk Fibroin As a Scaffold for Wound Dressing Applications, ACS Applied Materials and Interfaces (2021)
19. Biological Investigation of a Novel Nanocomposite Based on Functionalized Graphene Oxide Nanosheets With Pectin, Silk Fibroin and Zinc Chromite Nanoparticles, Journal of Biotechnology (2022)
20. A Review of the Use of Metallic Nanoparticles As a Novel Approach for Overcoming the Stability Challenges of Blood Products: A Narrative Review From 2011-2021, Current Drug Delivery (2023)
21. Unveiling the Synergy: Biocompatible Alginate-Cellulose Hydrogel Loaded With Silk Fibroin and Zinc Ferrite Nanoparticles for Enhanced Cell Adhesion, and Anti-Biofilm Activity, International Journal of Biological Macromolecules (2024)
22. Magnetic Xanthan Gum-Silk Fibroin Hydrogel: A Nanocomposite for Biological and Hyperthermia Applications, International Journal of Biological Macromolecules (2023)
23. Recent Progresses in Development of Biosensors for Thrombin Detection, Biosensors (2022)
24. Recent Advances in Gold Nanoparticles-Based Biosensors for Tuberculosis Determination, Talanta (2024)
25. Disease Specific Protein Corona, Progress in Biomedical Optics and Imaging - Proceedings of SPIE (2015)
26. Investigation of Biological Activity and Hyperthermia Application of a Quaternary Magnetic Nanobiocomposite Based on Functionalized Carbon Nitride Nanosheets by Carboxymethyl Cellulose Hydrogel and Silk Fibroin, Cellulose (2023)
27. Surface Modification and Bioconjugation of Anti-Cd4 Monoclonal Antibody to Magnetic Nanoparticles As a Highly Efficient Affinity Adsorbent for Positive Selection of Peripheral Blood T Cd4+ Lymphocytes, International Journal of Biological Macromolecules (2020)
28. Recent Advances on Hyperthermia Therapy Applications of Carbon-Based Nanocomposites, Colloids and Surfaces B: Biointerfaces (2023)
29. Nanoparticles and Biological Environment Interactions, Advanced Structured Materials (2019)
30. Codelivery of Hydrophobic and Hydrophilic Drugs by Graphene-Decorated Magnetic Dendrimers, Langmuir (2018)
31. A Novel Magnetic Nanocomposite Based on Alginate-Tannic Acid Hydrogel Embedded With Silk Fibroin With Biological Activity and Hyperthermia Application, International Journal of Biological Macromolecules (2023)
32. A Novel Ternary Magnetic Nanobiocomposite Based on Tragacanth-Silk Fibroin Hydrogel for Hyperthermia and Biological Properties, Scientific Reports (2024)
33. Superparamagnetic Iron Oxide Nanoparticles for in Vivo Molecular and Cellular Imaging, Contrast Media and Molecular Imaging (2015)
34. Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles in Different Tissues, Artificial Cells# Nanomedicine and Biotechnology (2020)
35. The Bio-Interface Between Functionalized Au Nr@Go Nanoplatforms With Protein Corona and Their Impact on Delivery and Release System, Colloids and Surfaces B: Biointerfaces (2019)
36. Protein Corona: Challenges and Opportunities for Cancer Therapy, Functionalized Nanomaterials for Cancer Research: Applications in Treatments# Tools and Devices (2024)
37. Fabrication and Biological Investigation of a Novel Star Polymer Based on Magnetic Cyclic Aromatic Polyimide Chains, Scientific Reports (2023)
38. Bypassing Protein Corona Issue on Active Targeting: Zwitterionic Coatings Dictate Specific Interactions of Targeting Moieties and Cell Receptors, ACS Applied Materials and Interfaces (2016)
39. Application of Functional Magnetic Nanoparticles for Separation of Target Materials: A Review, Current Nanoscience (2022)
40. Nanomaterials-Based Hyperthermia: A Literature Review From Concept to Applications in Chemistry and Biomedicine, Journal of Thermal Biology (2022)
41. Unveiling the Theranostic Potential of Spions in Alzheimer's Disease Management, Journal of Psychiatric Research (2024)
42. Nanotoxicology: Advances and Pitfalls in Research Methodology, Nanomedicine (2015)
43. Regulation of Macrophage Recognition Through the Interplay of Nanoparticle Surface Functionality and Protein Corona, ACS Nano (2016)
44. Impact of Protein Pre-Coating on the Protein Corona Composition and Nanoparticle Cellular Uptake, Biomaterials (2016)
45. Biomedical Applications of Superparamagnetic Nanoparticles in Molecular Scale, Current Organic Chemistry (2015)
46. Synthesis of Polyethyleneimine (Pei) and Β-Cyclodextrin Grafted Pei Nanocomposites With Magnetic Cores for Lipase Immobilization and Esterification, Journal of Chemical Technology and Biotechnology (2016)
47. Opportunities and Challenges of the Tag-Assisted Protein Purification Techniques: Applications in the Pharmaceutical Industry, Biotechnology Advances (2020)
48. Pegylated Magnetic Mesoporous Silica Nanoparticles Decorated With As1411 Aptamer As a Targeting Delivery System for Cytotoxic Agents, Pharmaceutical Development and Technology (2019)
49. Synthesis, Characterization, and the Investigation of the Applicability of Citric Acid Functionalized Fe2o3 Nanoparticles for the Extraction of Carvedilol From Human Plasma Using Dft Calculations and Clinical Samples Analysis, Microchemical Journal (2022)
50. Synthetic and Biological Identities of Polymeric Nanoparticles Influencing the Cellular Delivery: An Immunological Link, Journal of Colloid and Interface Science (2019)