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Recent Advances in the Synthesis of Heterocycles by the Aza-Wittig Reaction Publisher



Pedrood K1 ; Montazer MN2 ; Larijani B1 ; Mahdavi M1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Synthesis (Germany) Published:2021


Abstract

The formation of the C=N bond in recent studies on heterocyclic compounds via the aza-Wittig reaction is reviewed. Furthermore, two different strategies for the formation of heterocyclic compounds, including intermolecular and intramolecular aza-Wittig reactions are described. The primary aim of this review is to provide up-to-date information on the application of the aza-Wittig reaction in the synthesis of a wide range of N-containing heterocyclic compounds in the chemical literature since 2010. 1 Introduction 2 Mechanism of the Staudinger and Aza-Wittig Reactions 3 Intramolecular Aza-Wittig Reaction 4 Intermolecular Aza-Wittig Reaction 5 Conclusion. © 2021 EDP Sciences. All rights reserved.