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The Relation Between Oxygen Saturation Measured by Pulse Oximetry Vs Near-Infrared Spectroscopy Following Surfactant Therapy in Very Low-Birth-Weight Neonates Publisher



Veisizadeh M1 ; Afjehi SA2 ; Zarkesh MR3, 4 ; Kazemian M5 ; Shafaeizadeh A6 ; Khedmat L7
Authors
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Authors Affiliations
  1. 1. Department of Neonatology, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Mahdieh Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Neonatology, Yas Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Maternal, Fetal, and Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Neonatal Health Research Center, Institute for Children’s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Health Technology Research Center, Amirkabir University of Technology, Tehran, Iran
  7. 7. Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pediatrics Published:2023


Abstract

Background: Monitoring regional cerebral oxygen saturation (rScO2) and hemodynamic stability (eg, mean arterial blood pressure [MABP]) in high-risk premature infants is crucial to enhance daily clinical practices in neonatal intensive care units (NICUs). Objectives: This study aimed to investigate potential differences between oxygen saturation measurements obtained via near-infrared spectroscopy (NIRS) and pulse oximetry (PO). Methods: This pilot study enrolled 20 very low-birth-weight (VLBW) premature neonates through a non-random, available sampling approach. We gathered maternal and fetal demographic data along with clinical characteristics of the neonates. The study focused on assessing tissue and cerebral oxygenation using PO and NIRS. We specifically monitored changes in mean rScO2 and MABP at various time points: before, during, and 5 and 10 min after the administration of surfactant injection (SI) via the endotracheal tube. Results: The mean gestational age, neonatal birth weight, and Apgar scores at 1 and 5 min after birth were 28.44 ± 2.57 weeks, 1063 ± 246 g, 6.05 ± 2.57, and 7.94 ± 1.79, respectively. No significant differences were observed between mean rScO2 values measured by NIRS and PO before (P = 0.631), during (P = 0.722), and 5 min after (P = 0.783) SI. However, a significant difference between PO and NIRS-based rScO2 values was found 10 min after SI (96.95% vs 75.0%; P = 0.04). Additionally, there was no significant correlation between mean rScO2 and MABP recorded before, during, and after SI. Conclusions: There were no differences in oxygen saturation measurements (recorded by PO) and rScO2 values (recorded by NIRS) before, during, and immediately after SI. Therefore, using PO in NICUs to assess cerebral oxygenation, autoregulation, and hypoxia appears both reasonable and cost-effective. Further multicenter studies are needed to validate the practical advantages and cost-effectiveness of NIRS as an emerging monitoring system. © 2023, Veisizadeh et al.