Oxytocin Is Involved in the Proconvulsant Effects of Sildenafil: Possible Role of Creb

Oxytocin Is Involved in the Proconvulsant Effects of Sildenafil: Possible Role of Creb Publisher Pubmed

Khoshneviszadeh M¹ ; Rahimian R^{1, 2} ; Fakhfouri G² ; Payandemehr B¹ ; Khodagholi F³ ; Ejtemaei Mehr S¹ ; Dehpour AR^{1, 4}

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1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Psychiatry and Neuroscience, Faculty of Medicine, Research Center of the Mental Health Institute of Quebec, Laval University, Quebec, G1J 2G3, QC, Canada
3. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Toxicology Letters Published:2016

Abstract

Sildenafil is a phosphodiesterase type 5 inhibitor mainly used for male erectile dysfunction. One of rare yet serious adverse effects of Sildenafil is its potential to decrease seizure threshold. Ample evidence suggests that Sildenafil exerts central effects through induction of Oxytocin (OT) secretion and CREB phosphorylation. The aim of the present study is to evaluate potential roles of OT and CREB in the proconvulsant effects of Sildenafil.The Pentylenetetrazole-induced seizure was used as a standard convulsion model in this study. OT release and pCREB expression were evaluated in the hippocampus of mice using ELISA and western blot assays, respectively.Our results showed that Sildenafil at the dose of 10 mg kg-1 or higher, significantly decreased seizure threshold. Pretreatment with a non-effective dose of OT, potentiated while OT receptor antagonist, Atosiban, reversed fully the proconvulsant effects of Sildenafil (5 mg kg-1). At biochemical inspection, Sildenafil markedly increased CREB which was attenuated by coadministration of Atosiban.The present study shows for the first time that OT release and the subsequent CREB phosphorylation are involved in the proconvulsant effects of acute Sildenafil treatment in an experimental model of seizure. © 2016 Elsevier Ireland Ltd.

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Ahmad Reza Dehpour (11)

Mohammad Sharifzadeh (1)

Style	Citing Format
MLA	Khoshneviszadeh M, et al.. "Oxytocin Is Involved in the Proconvulsant Effects of Sildenafil: Possible Role of Creb." Toxicology Letters, vol. 256, no. , 2016, pp. 44-52.
APA	Khoshneviszadeh M, Rahimian R, Fakhfouri G, Payandemehr B, Khodagholi F, Ejtemaei Mehr S, Dehpour AR (2016). Oxytocin Is Involved in the Proconvulsant Effects of Sildenafil: Possible Role of Creb. Toxicology Letters, 256(), 44-52.
Chicago	Khoshneviszadeh M, Rahimian R, Fakhfouri G, Payandemehr B, Khodagholi F, Ejtemaei Mehr S, Dehpour AR. "Oxytocin Is Involved in the Proconvulsant Effects of Sildenafil: Possible Role of Creb." Toxicology Letters 256, no. (2016): 44-52.
Harvard	Khoshneviszadeh M et al. (2016) 'Oxytocin Is Involved in the Proconvulsant Effects of Sildenafil: Possible Role of Creb', Toxicology Letters, 256(), pp. 44-52.
Vancouver	Khoshneviszadeh M, Rahimian R, Fakhfouri G, Payandemehr B, Khodagholi F, Ejtemaei Mehr S, et al.. Oxytocin Is Involved in the Proconvulsant Effects of Sildenafil: Possible Role of Creb. Toxicology Letters. 2016;256():44-52.
BibTex	@article{ author = {Khoshneviszadeh M and Rahimian R and Fakhfouri G and Payandemehr B and Khodagholi F and Ejtemaei Mehr S and Dehpour AR}, title = {Oxytocin Is Involved in the Proconvulsant Effects of Sildenafil: Possible Role of Creb}, journal = {Toxicology Letters}, volume = {256}, number = {}, pages = {44-52}, year = {2016} }
RIS	TY - JOUR AU - Khoshneviszadeh M AU - Rahimian R AU - Fakhfouri G AU - Payandemehr B AU - Khodagholi F AU - Ejtemaei Mehr S AU - Dehpour AR TI - Oxytocin Is Involved in the Proconvulsant Effects of Sildenafil: Possible Role of Creb JO - Toxicology Letters VL - 256 IS - SP - 44 EP - 52 PY - 2016 ER -

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