Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders Publisher Pubmed



Farzaei MH1 ; Singh AK2 ; Kumar R2 ; Croley CR3 ; Pandey AK2 ; Coybarrera E4 ; Patra JK5 ; Das G5 ; Kerry RG6 ; Annunziata G7 ; Tenore GC7 ; Khan H8 ; Micucci M9 ; Budriesi R9 Show All Authors
Authors
  1. Farzaei MH1
  2. Singh AK2
  3. Kumar R2
  4. Croley CR3
  5. Pandey AK2
  6. Coybarrera E4
  7. Patra JK5
  8. Das G5
  9. Kerry RG6
  10. Annunziata G7
  11. Tenore GC7
  12. Khan H8
  13. Micucci M9
  14. Budriesi R9
  15. Momtaz S10, 11
  16. Nabavi SM12
  17. Bishayee A3
Show Affiliations
Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran
  2. 2. Department of Biochemistry, University of Allahabad, Allahabad, 211 002, India
  3. 3. Lake Erie College of Osteopathic Medicine, Bradenton, 34211, FL, United States
  4. 4. Bioorganic Chemistry Laboratory, Facultad de Ciencias Basicas y Aplicadas, Campus Nueva Granada, Universidad Militar Nueva Granada, Cajica, 250247, Colombia
  5. 5. Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Gyeonggi-do, 10326, South Korea
  6. 6. Post Graduate Department of Biotechnology, Utkal University, Vani Vihar, Bhubaneswar, 751 004, Odisha, India
  7. 7. Department of Pharmacy, University of Naples “Federico II�, Via Domenico Montesano 49, Naples, 80131, Italy
  8. 8. Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan
  9. 9. Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Bologna, 40126, Italy
  10. 10. Medicinal Plants Research Center, Institute of Medicinal Plants, Karaj, 141554364, Iran
  11. 11. Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran, 141556451, Iran
  12. 12. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, 1435916471, Iran

Source: International Journal of Molecular Sciences Published:2019


Abstract

A balanced metabolic profile is essential for normal human physiological activities. Disproportions in nutrition give rise to imbalances in metabolism that are associated with aberrant immune function and an elevated risk for inflammatory-associated disorders. Inflammation is a complex process, and numerous mediators affect inflammation-mediated disorders. The available clinical modalities do not effectively address the underlying diseases but rather relieve the symptoms. Therefore, novel targeted agents have the potential to normalize the metabolic system and, thus, provide meaningful therapy to the underlying disorder. In this connection, polyphenols, the well-known and extensively studied phytochemical moieties, were evaluated for their effective role in the restoration of metabolism via various mechanistic signaling pathways. The various flavonoids that we observed in this comprehensive review interfere with the metabolic events that induce inflammation. The mechanisms via which the polyphenols, in particular flavonoids, act provide a promising treatment option for inflammatory disorders. However, detailed clinical studies of such molecules are required to decide their clinical fate. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Related Docs
View other Related Docs
1. Citrus Flavonoids and Adhesion Molecules: Potential Role in the Management of Atherosclerosis, Heliyon (2023)
2. Dietary Polyphenols for Atherosclerosis: A Comprehensive Review and Future Perspectives, Critical Reviews in Food Science and Nutrition (2019)
3. Effects of Quercetin Supplementation on Glycemic Control Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2019)
4. The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Current Pharmaceutical Design (2019)
5. Effect of Dark Chocolate on Flow-Mediated Dilatation: Systematic Review, Meta-Analysis, and Dose–Response Analysis of Randomized Controlled Trials, Clinical Nutrition ESPEN (2020)
6. Does Cocoa/Dark Chocolate Supplementation Have Favorable Effect on Body Weight, Body Mass Index and Waist Circumference? a Systematic Review, Meta-Analysis and Dose-Response of Randomized Clinical Trials, Critical Reviews in Food Science and Nutrition (2019)
7. Endoplasmic Reticulum As a Target in Cardiovascular Diseases: Is There a Role for Flavonoids?, Frontiers in Pharmacology (2023)
8. The Mental Burden of Immunoperception, Biophysics and Neurophysiology of the Sixth Sense (2019)
Experts (# of related papers)
View all Related Experts
Sakineh Shab-Bidar (10)
Nima Rezaei (7)
Other Related Docs
9. The Roles of Quercetin in Diabetes Mellitus and Related Metabolic Disorders; Special Focus on the Modulation of Gut Microbiota: A Comprehensive Review, Critical Reviews in Food Science and Nutrition (2023)
10. Fermented Foods and Inflammation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Clinical Nutrition ESPEN (2020)
11. The Effects of Hesperidin Supplementation on Cardiovascular Risk Factors in Adults: A Systematic Review and Dose–Response Meta-Analysis, Frontiers in Nutrition (2023)
12. Therapeutic Potential of Flavonoids in Inflammatory Bowel Disease: A Comprehensive Review, World Journal of Gastroenterology (2017)
13. Hesperidin Improves Hepatic Steatosis, Hepatic Enzymes, and Metabolic and Inflammatory Parameters in Patients With Nonalcoholic Fatty Liver Disease: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial, Phytotherapy Research (2019)
14. The Effect of Hesperidin Supplementation on Metabolic Profiles in Patients With Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, European Journal of Nutrition (2020)
15. Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review, Frontiers in Pharmacology (2018)
16. Targeting Mitogen-Activated Protein Kinases by Natural Products: A Novel Therapeutic Approach for Inflammatory Bowel Diseases, Current Pharmaceutical Biotechnology (2020)
17. Hesperidin Reduces Serum Levels of Triglyceride After Coronary Artery Bypass Graft Surgery, Food Science and Nutrition (2023)
18. The Effects of Green Tea Extract Supplementation on Body Composition, Obesity-Related Hormones and Oxidative Stress Markers: A Grade-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomised Controlled Trials, British Journal of Nutrition (2024)
19. Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review, Frontiers in Bioengineering and Biotechnology (2020)
20. A Glance at the Therapeutic Potential of Irisin Against Diseases Involving Inflammation, Oxidative Stress, and Apoptosis: An Introductory Review, Pharmacological Research (2018)
21. The Effects of Green Tea Supplementation on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis, Frontiers in Nutrition (2023)
22. The Effect of Insomnia on Development of Alzheimer's Disease, Journal of Neuroinflammation (2020)
23. Untangling Narcolepsy and Diabetes: Pathomechanisms With Eyes on Therapeutic Options, Brain Research (2019)
24. Dietary Inflammatory Index: A Potent Association With Cardiovascular Risk Factors Among Patients Candidate for Coronary Artery Bypass Grafting (Cabg) Surgery, Nutrition Journal (2018)
25. A Comprehensive Systematic Review of the Effects of Naringenin, a Citrus-Derived Flavonoid, on Risk Factors for Nonalcoholic Fatty Liver Disease, Advances in Nutrition (2021)
26. Diabetes Management by Probiotics: Current Knowledge and Future Perspectives, International Journal for Vitamin and Nutrition Research (2016)
27. Dietary Inflammatory Index and Dietary Energy Density Are Associated With Menopausal Symptoms in Postmenopausal Women: A Cross-Sectional Study, Menopause (2020)
28. Heterocyclic Compounds: Effective Α-Amylase and Α-Glucosidase Inhibitors, Current Topics in Medicinal Chemistry (2017)
29. Bioactive Foods and Medicinal Plants for Cardiovascular Complications of Type Ii Diabetes: Current Clinical Evidence and Future Perspectives, Evidence-based Complementary and Alternative Medicine (2021)
30. Effects of Grape Products on Blood Lipids: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Food and Function (2019)
31. Crosstalk Between Autophagy and Insulin Resistance: Evidence From Different Tissues, European Journal of Medical Research (2023)
32. Association of Dietary Insulinaemic Potential and Odds of Non-Alcoholic Fatty Liver Disease Among Adults: A Case–Control Study, Journal of Human Nutrition and Dietetics (2021)
33. Signaling Pathways Linking Inflammation to Insulin Resistance, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
34. Targeting Dyslipidemia by Herbal Medicines: A Systematic Review of Meta-Analyses, Journal of Ethnopharmacology (2021)
35. Association of Dietary and Lifestyle Inflammation Score With Metabolic Syndrome in a Sample of Iranian Adults, Frontiers in Nutrition (2021)
36. Cardiovascular Disease and Cancer: Evidence for Shared Disease Pathways and Pharmacologic Prevention, Atherosclerosis (2017)
37. Molecular Mechanisms of Curcumins Suppressing Effects on Tumorigenesis, Angiogenesis and Metastasis, Focusing on Nf-Κb Pathway, Cytokine and Growth Factor Reviews (2016)
38. Pleotropic Effects of Polyphenols in Cardiovascular System, Biomedicine and Pharmacotherapy (2020)
39. Harnessing the Fundamental Roles of Vitamins: The Potent Anti-Oxidants in Longevity, Biogerontology (2025)
40. A New Bioactive Monoterpene-Flavonoid From Satureja Khuzistanica, Fitoterapia (2015)
41. Are Alterations Needed in Silybum Marianum (Silymarin) Administration Practices? a Novel Outlook and Meta-Analysis on Randomized Trials Targeting Liver Injury, BMC Complementary Medicine and Therapies (2025)
42. Effect of Resveratrol on Metabolic Syndrome Components: A Systematic Review and Meta-Analysis, Reviews in Endocrine and Metabolic Disorders (2019)
43. Tropisetron Suppresses Colitis-Associated Cancer in a Mouse Model in the Remission Stage, International Immunopharmacology (2016)
44. The Association Between Nonalcoholic Fatty Liver Disease and Corrected Qt Interval Prolongation Among Generally Healthy Iranian Population: Fasa Cohort Study (Facs), Clinical Cardiology (2023)
45. Targeting Mammalian Target of Rapamycin: Prospects for the Treatment of Inflammatory Bowel Diseases, Current Medicinal Chemistry (2021)
46. A Systematic Review and Meta-Analysis of the Impact of Cornelian Cherry Consumption on Blood Lipid Profiles, Food Science and Nutrition (2021)
47. The Future of Diabetes Management by Healthy Probiotic Microorganisms, Current Diabetes Reviews (2017)
48. The Effects of Acarbose Treatment on Cardiovascular Risk Factors in Impaired Glucose Tolerance and Diabetic Patients: A Systematic Review and Dose–Response Meta-Analysis of Randomized Clinical Trials, Frontiers in Nutrition (2023)
49. Effects of Genistein on Blood Pressure: A Systematic Review and Meta-Analysis, Food Research International (2020)
50. Flavonoids Target Different Molecules of Autophagic and Metastatic Pathways in Cancer Cells, Cancer Cell International (2023)