The Impact of Osteosarcopenia and Its Parameters on Mortality of Covid-19 In-Hospitalized Older Patients: The Findings of Beh (Bushehr Elderly Health) Program Publisher



Shafiee G¹ ; Marzban M² ; Abbaspour F¹ ; Darabi A³ ; Balajam NZ¹ ; Farhadi A³ ; Khaleghi MM^{3, 4} ; Taherzadeh H⁵ ; Fahimfar N⁶ ; Falahatzadeh A⁷ ; Ghasemi N⁷ ; Ostovar A⁶ ; Nabipour I³ ; Larijani B⁸ Show All Authors Show Affiliations
Source: Journal of Diabetes and Metabolic Disorders Published:2024

Abstract

Background: It has been documented that old age and chronic diseases are associated with poor prognosis and mortality among COVID-19 patients. Osteosarcopenia is a geriatric syndrome with a considerable prevalence which increases morbidity and mortality. This study investigated the relationship between COVID-19 mortality and osteosarcopenia and its parameters in-hospitalized patients in Bushehr, Iran. Methods: In this retrospective cohort study, participants of the Bushehr Elderly Health (BEH) program who were hospitalized due to COVID-19 between 1st March 2020 and 23rd September 2021 were assessed. Osteosarcopenia was considered as the presence of both osteopenia/osteoporosis and sarcopenia. We used the Cox proportional hazards model to identify the association between oteosarcopenia and the risk of COVID-mortality in 2442 person-days. Results: Among 4173 participants,297 patients were in-hospitalized due to COVID-19. We found that 80(26.94%) patients expired due to COVID-19 during the follow-up period. Osteosarcopenia and its parameters were more prevalent in patients who expired. The incidence rate of mortality among osteosarcopenic patients was 5.04(3.43– 7.40) per 100 person-days. In the Cox proportional hazards models, osteosarcopenia and its parameters increase the risk of COVID-mortality [Osteosarcopenia: HRadjusment:1.73(1.00-3.01), sarcopenia: HRadjusment:1.72(1.00-2.99), Osteoporosis: HRadjusment:2.67(1.53–4.67), Low muscle mass: HRadjusment:1.90(1.05–3.46), low muscle strength: HRadjusment:1.80(1.03–3.16), and low gait speed: HRadj:2.39(1.31–4.38). The ORs of ICU admission and use of invasive mechanical ventilation among osteosarcopenic patients and its parameters were higher than those without it. Conclusions: This study identified the impact of osteosarcopenia and its parameters on the mortality of in-hospitalized patients with COVID-19. Assessment of musculoskeletal disorders could help in early warning of older patients with severe COVID-19. © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024.