Comparison Pregnancy Outcomes Between Minimal Stimulation Protocol and Conventional Gnrh Antagonist Protocols in Poor Ovarian Responders



Pilehvari S¹ ; Shahrokh Tehraninejad E¹ ; Hosseinrashidi B¹ ; Keikhah F¹ ; Haghollahi F¹ ; Aziminekoo E¹ Show Affiliations
Source: Journal of Family and Reproductive Health Published:2016

Abstract

Objective: To compare the pregnancy outcomes achieved by in vitro fertilization (IVF) between minimal stimulation and conventional antagonist protocols in poor ovarian responders (PORs). Materials and methods: In this randomized controlled trial, 77 PORs undergoing IVF were selected and divided into two groups. First group was the minimal stimulation group (n = 42) receiving 100 mg/day clomiphene citrate on day 2of the cycle for 5 day that was followed by150IU/day human menopausal gonadotropin (hMG) on day 5 of the cycle. Second group was the conventional group (n = 35) receiving at least 300 IU/daygonadotropin on day 2 of the cycle. Gonadotropin-releasing hormone (GnRH) antagonist protocol was applied for both groups according to flexible protocol. Number of retrieved oocytes and chemical pregnancy rate were the main outcomes. Results: There was no difference in number ofretrieved oocyte and pregnancy rate (2.79 ± 1.96 vs. 2.20 ± 1.71 and 5.6% vs. 4.1%; p > 0.05) between both groups. The gonadotropin dose used in the minimal stimulation group was lower than conventional group (1046 ± 596 vs. 2806 ± 583). Conclusion: Minimal stimulation protocol with lower gonadotropin used is likely to be considered as a patientfriendly and cost-effective substitute for PORs. © 2016, Tehran University of Medical Sciences (TUMS). All rights reserved.