Early Onset Steroid Induced Posterior Subcapsular Cataract in a Patient With Common Variable Immunodeficiency: Case Reports and Review of Literature Pubmed



Marefat H^{1, 2, 3, 4} ; Abolhassani H^{1, 2, 3, 4} ; Ghareje Daghi M^{1, 2, 3, 4} ; Azizi G^{1, 2, 3, 4} ; Aghamohammadi A^{1, 2, 3, 4}
Source: European annals of allergy and clinical immunology Published:2016

Abstract

Purpose. To report early onset steroid induced posterior subcapsular cataract in a case of common variable immunodeficiency. Methods. Case report. Results. Here we report a 14-yearold male of steroid induced bilateral posterior subcapsular cataract in a common variable immunodeficiency patient with damaging mutations in Glutathione reductase gene, leading to hypersensitivity of patient to glucocorticoid (GC) products. Conclusions. In order to reduce the ocular side effects of the GCs there are some advisements, including a complete history, regular examination, GC should be prescribed in minimal dosage and minimal course, and as possible GC-sparing drugs should always be considered.