A Prospective Double-Blinded Randomized Controlled Trial Comparing Systemic Stress Response in Laparoascopic Cholecystectomy Between Low-Pressure and Standard-Pressure Pneumoperitoneum

A Prospective Double-Blinded Randomized Controlled Trial Comparing Systemic Stress Response in Laparoascopic Cholecystectomy Between Low-Pressure and Standard-Pressure Pneumoperitoneum Publisher Pubmed

Shoar S¹ ; Naderan M¹ ; Ebrahimpour H¹ ; Soroush A^{1, 2} ; Nasiri S^{1, 2} ; Movafegh A¹ ; Khorgami Z^{1, 2}

Show Affiliations

1. Department of Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Research Center for Improvement of Surgical Outcomes and Procedures, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Surgery Published:2016

Abstract

Introduction: Laparoscopic cholecystectomy (LC) has become the gold-standard treatment for gallstone diseases. However, despite huge reduction in operative injury, systemic stress response remains high. This randomized controlled trial (RCT) aimed to compare systemic stress response between 2 different techniques of CO2 pneumoperitoneum. Methods: Trough a prospective, double-blinded RCT, serum levels of cortisol, adrenaline, glucose, and C-reactive protein (CRP) were compared between the two groups consisted of 50 patients undergoing LC under low-pressure and standard-pressure CO2 pneimoperitoneum. Results: A total of fifty patients undergoing LC were equally assigned to 2 groups of twenty five patients. Average age was 48 ± 13.8 years (range, 19-74 years). Operative time was similar between standard-pressure group (47.8 ± 16.8 min) and low-pressure group (53.6 ± 25.1). Moreover, intra-operative IV volume administration and urine output did not differ significantly between the 2 groups (p > 0.05). Although the average heart rate and mean arterial pressure were slightly higher in a standard-pressure group compared with a low-pressure group, serial measurements of these parameters were statistically similar between the 2 groups. Serial changes of serum levels of cortisol, glucose, adrenaline, and CRP were compared between surgery day, postoperative 6-h and 1st postoperative day, which did not differ significantly between the standard-pressure and the low-pressure groups (p > 0.05). Conclusion: Our study did not reveal any alteration in systemic stress response with reduction in intra-abdominal pressure of pneumoperitoneum in LC. RCT Registration: irct.ir ID: IRCT201110072982N5. © 2016 IJS Publishing Group Limited.

Style	Citing Format
MLA	Shoar S, et al.. "A Prospective Double-Blinded Randomized Controlled Trial Comparing Systemic Stress Response in Laparoascopic Cholecystectomy Between Low-Pressure and Standard-Pressure Pneumoperitoneum." International Journal of Surgery, vol. 28, no. , 2016, pp. 28-33.
APA	Shoar S, Naderan M, Ebrahimpour H, Soroush A, Nasiri S, Movafegh A, Khorgami Z (2016). A Prospective Double-Blinded Randomized Controlled Trial Comparing Systemic Stress Response in Laparoascopic Cholecystectomy Between Low-Pressure and Standard-Pressure Pneumoperitoneum. International Journal of Surgery, 28(), 28-33.
Chicago	Shoar S, Naderan M, Ebrahimpour H, Soroush A, Nasiri S, Movafegh A, Khorgami Z. "A Prospective Double-Blinded Randomized Controlled Trial Comparing Systemic Stress Response in Laparoascopic Cholecystectomy Between Low-Pressure and Standard-Pressure Pneumoperitoneum." International Journal of Surgery 28, no. (2016): 28-33.
Harvard	Shoar S et al. (2016) 'A Prospective Double-Blinded Randomized Controlled Trial Comparing Systemic Stress Response in Laparoascopic Cholecystectomy Between Low-Pressure and Standard-Pressure Pneumoperitoneum', International Journal of Surgery, 28(), pp. 28-33.
Vancouver	Shoar S, Naderan M, Ebrahimpour H, Soroush A, Nasiri S, Movafegh A, et al.. A Prospective Double-Blinded Randomized Controlled Trial Comparing Systemic Stress Response in Laparoascopic Cholecystectomy Between Low-Pressure and Standard-Pressure Pneumoperitoneum. International Journal of Surgery. 2016;28():28-33.
BibTex	@article{ author = {Shoar S and Naderan M and Ebrahimpour H and Soroush A and Nasiri S and Movafegh A and Khorgami Z}, title = {A Prospective Double-Blinded Randomized Controlled Trial Comparing Systemic Stress Response in Laparoascopic Cholecystectomy Between Low-Pressure and Standard-Pressure Pneumoperitoneum}, journal = {International Journal of Surgery}, volume = {28}, number = {}, pages = {28-33}, year = {2016} }
RIS	TY - JOUR AU - Shoar S AU - Naderan M AU - Ebrahimpour H AU - Soroush A AU - Nasiri S AU - Movafegh A AU - Khorgami Z TI - A Prospective Double-Blinded Randomized Controlled Trial Comparing Systemic Stress Response in Laparoascopic Cholecystectomy Between Low-Pressure and Standard-Pressure Pneumoperitoneum JO - International Journal of Surgery VL - 28 IS - SP - 28 EP - 33 PY - 2016 ER -

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