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Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior Publisher



Mirfazeli FS1 ; Mohebi F2 ; Jahanbakhshi A3 ; Aryani O4, 5 ; Almasidooghaee M6
Authors

Source: Basic and Clinical Neuroscience Published:2022


Abstract

Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS. © 2023 Istanbul Tip Fakultesi Dergisi. All rights reserved.