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Tissue Fatty Acid Composition and Secretory Phospholipase-A2 Activity in Oral Squamous Cell Carcinoma Publisher Pubmed



Askari M1 ; Darabi M2 ; Zare Mahmudabadi R3 ; Oboodiat M1 ; Fayezi S4 ; Mostakhdemin Hosseini Z5 ; Pirzadeh A6
Authors
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Authors Affiliations
  1. 1. Department of Maxillofacial Pathology, International Campus, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Institute of Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland
  3. 3. Department of Maxillofacial Pathology, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Anatomy and Cell Biology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Tumor Bank, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Clinical and Translational Oncology Published:2015


Abstract

Purpose: Oral squamous cell carcinoma (OSCC) is a remarkable health problem worldwide, but its pathogenesis remains unknown. The aim of this study was to compare fat composition and secretory phospholipase-A2 (sPLA2) activity between the malignant and adjacent normal squamous tissues in patients with OSCC. Methods: Paired samples of malignant squamous and adjacent normal-appearing tissues were collected from 27 patients with OSCC. The fatty acid composition in the obtained tissues was determined by gas liquid chromatography. Tissue enzyme activities of sPLA2 were measured using the standard assay with Diheptanoyl Thio-Phosphatidylcholine as substrate. Results: In the OSCC tissue, the level of stearic acid (18:0) and activity of sPLA2 were higher (P < 0.001), and the levels of oleic acid (18:1n-9) and linoleic acid (18:2n-6) were lower than that in the adjacent normal-appearing squamous tissue (P < 0.001). The activity of sPLA2 in OSCC was strongly negatively correlated with the amount of 18:2n-6 (r = −0.41, P < 0.001). Negative significant associations were observed between the OSCC invasion and tissue levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHE). Conclusion: The changes in the fatty acid composition and sPLA2 activity may be regarded as indicators of altered lipid metabolism occurring in vivo during squamous cell carcinogenesis. © 2014, Federacion de Sociedades Espanolas de Oncologia (FESEO).
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