Centiserver: A Comprehensive Resource, Web-Based Application and R Package for Centrality Analysis Publisher Pubmed



Jalili M¹ ; Salehzadehyazdi A¹ ; Asgari Y² ; Arab SS^{2, 3} ; Yaghmaie M¹ ; Ghavamzadeh A¹ ; Alimoghaddam K¹ Show Affiliations
Source: PLoS ONE Published:2015

Abstract

Various disciplines are trying to solve one of the most noteworthy queries and broadly used concepts in biology, essentiality. Centrality is a primary index and a promising method for identifying essential nodes, particularly in biological networks. The newly created CentiServer is a comprehensive online resource that provides over 110 definitions of different centrality indices, their computational methods, and algorithms in the form of an encyclopedia. In addition, CentiServer allows users to calculate 55 centralities with the help of an interactive web-based application tool and provides a numerical result as a comma separated value (csv) file format or a mapped graphical format as a graph modeling language (GML) file. The standalone version of this application has been developed in the form of an R package. The web-based application (CentiServer) and R package (centiserve) are freely available at http://www.centiserver.org. © 2015 Jalili et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.