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Effect of Rose Oil on Gastroesophageal Reflux Disease in Comparison With Omeprazole: A Double-Blind Controlled Trial Publisher Pubmed



Adel Mehraban MS1 ; Shirzad M1 ; Ahmadianattari MM2, 3 ; Shakeri R4 ; Taghizadeh Kashani LM5 ; Tabarrai M1 ; Shirbeigi L1
Authors
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Authors Affiliations
  1. 1. School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Evidence-based Phytotherapy and Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Department of Pharmacognosy, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran
  4. 4. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Traditional Medicine, Medicinal Plants Research Center of Barij, Kashan, Iran

Source: Complementary Therapies in Clinical Practice Published:2021


Abstract

Background and objective: Gastroesophageal reflux disease (GERD) as one of the most common ailments of gastrointestinal system diminishes quality of life and impairs physical functioning and work productivity. Proton-pump inhibitors (PPIs), such as omeprazole play a more dominant role in amelioration of GERD symptoms; nonetheless, there is a growing concern about their side effects. According to traditional Persian medicine (TPM), the use of rose oil is recommended to alleviate GERD symptoms. Materials and methods: Therefore, a randomized double-blind controlled trial was performed on 70 subjects who were randomly enrolled in two groups and received either rose oil softgel or omeprazole capsule combined with the placebo. Data were collected within 3 sessions of visit using the Mayo-gastroesophageal reflux questionnaire (GERQ). Results: Although, our findings showed that reflux symptoms were decreased in both groups after receiving medicine and the decrement was significant in treatment group, before and after the intervention, this decrease was not significant between two groups. Conclusion: Given that the rose oil used in this study was produced according to the Iranian method and effective ingredients of Rosa damascena were preserved in sesame oil in production process, it seems that effectiveness of this product can be due to its tonic and enlivening properties. Consumption of rose oil soft capsule alleviates cardinal GERD symptoms similar to omeprazole. It seems that rose oil can have the same effects as PPIs in treatment of GERD but with no side effects due to its different mechanisms of action. © 2021 Elsevier Ltd
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