Expression of Osteopontin-5 Splice Variant in the Mouse Primary and Metastatic Breast Cancer Cells

Expression of Osteopontin-5 Splice Variant in the Mouse Primary and Metastatic Breast Cancer Cells Publisher Pubmed

Kamalabadifarahani M¹ ; Atashi A² ; Jabbarpour Z³ ; Aghayan SS³

Show Affiliations

1. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
2. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran
3. Gene Therapy Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Research Notes Published:2022

Abstract

Objective: Osteopontin (OPN) is a well-known glycoprotein involved in numerous pathobiological processes, including cancer. Despite having five splice variants for osteopontin in mice, the main focus of most studies has been on total OPN (tOPN). There are some studies on other splice variants, but the expression of osteopontin-5 (OPN5) has not been addressed in mouse cancer cells. Therefore, this study sought to evaluate OPN5 expression in mouse breast cancer cells. Results: The expression of OPN5 in primary and metastatic breast cancer cells of mice was confirmed in our study. These findings provided important insights regarding the OPN alternative splicing in mice for the first time. It is concluded that, like other OPN-SVs, OPN5 probably plays an essential role in tumor progression, which requires further investigation in different tumor models. © 2022, The Author(s).

2. Evaluation of Anticancer Effects of Frankincense on Breast Cancer Stem-Like Cells, Cancer Reports (2023)

3. Osteopontin B and C Splice Isoforms in Leukemias and Solid Tumors: Angiogenesis Alongside Chemoresistance, Asian Pacific Journal of Cancer Prevention (2018)

4. Quercetin Can Be a More Reliable Treatment for Metastatic Prostate Cancer Than the Localized Disease: An in Vitro Study, Journal of Cellular and Molecular Medicine (2023)

Experts (# of related papers)

View all Related Experts

Saeed Mohammadi (2)

Seyed Hamidollah Ghaffari (2)

Style	Citing Format
MLA	Kamalabadifarahani M, et al.. "Expression of Osteopontin-5 Splice Variant in the Mouse Primary and Metastatic Breast Cancer Cells." BMC Research Notes, vol. 15, no. 1, 2022, pp. -.
APA	Kamalabadifarahani M, Atashi A, Jabbarpour Z, Aghayan SS (2022). Expression of Osteopontin-5 Splice Variant in the Mouse Primary and Metastatic Breast Cancer Cells. BMC Research Notes, 15(1), -.
Chicago	Kamalabadifarahani M, Atashi A, Jabbarpour Z, Aghayan SS. "Expression of Osteopontin-5 Splice Variant in the Mouse Primary and Metastatic Breast Cancer Cells." BMC Research Notes 15, no. 1 (2022): -.
Harvard	Kamalabadifarahani M et al. (2022) 'Expression of Osteopontin-5 Splice Variant in the Mouse Primary and Metastatic Breast Cancer Cells', BMC Research Notes, 15(1), pp. -.
Vancouver	Kamalabadifarahani M, Atashi A, Jabbarpour Z, Aghayan SS. Expression of Osteopontin-5 Splice Variant in the Mouse Primary and Metastatic Breast Cancer Cells. BMC Research Notes. 2022;15(1):-.
BibTex	@article{ author = {Kamalabadifarahani M and Atashi A and Jabbarpour Z and Aghayan SS}, title = {Expression of Osteopontin-5 Splice Variant in the Mouse Primary and Metastatic Breast Cancer Cells}, journal = {BMC Research Notes}, volume = {15}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Kamalabadifarahani M AU - Atashi A AU - Jabbarpour Z AU - Aghayan SS TI - Expression of Osteopontin-5 Splice Variant in the Mouse Primary and Metastatic Breast Cancer Cells JO - BMC Research Notes VL - 15 IS - 1 SP - EP - PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract