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Prevalence of Legionella Pneumophila Among Patients Suffering From Pneumonia: A Middle East Systematic Review and Meta-Analysis Publisher



Mohseni F1, 2 ; Khaledi A3
Authors
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Authors Affiliations
  1. 1. Department of Anesthesiology, Nursing School, Gerash University of Medical Sciences, Gerash, Iran
  2. 2. Department of Medical Education, Medical School, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology and Immunology, Faculty of Medicine, Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

Source: Reviews and Research in Medical Microbiology Published:2022


Abstract

Up to 90% of Legionella infections are caused by Legionella pneumophila including Legionnaires’ diseases, community-acquired pneumonia and nosocomial pneumonia. Therefore, the present systematic review and meta-analysis aimed to study the epidemiology of L. pneumophila retrieved from patients with pneumonia and respiratory tract infections from the Middle East. We searched PubMed, Scopus and Web of Science databases with restriction dates (restricting the search on cross-sectional studies published since 2000–20 April 2020), and languages (only English) with following Medical Subject Headings (Mesh) and text words; ‘Legionellosis’, ‘Legionnaire’, ‘Legionnaires disease’, ‘Legionellosis’, ‘Legionella’, ‘Legionella pneumophila’, ‘Middle East’, ‘Kuwait’, ‘Yemen’, ‘Iran’, ‘clinical samples’, ‘Turkey’, ‘Egypt’, ‘Saudi Arabia’, ‘Qatar’, ‘Syria’, ‘Lebanon’, ‘Bahrain’, ‘Iraq’, ‘Cyprus’, ‘Palestine’, ‘Israel’, ‘Jordan’, ‘Oman’ and ‘United Arab Emirates’, ‘respiratory symptoms’ and ‘pneumonia’. Descriptive statistics were computed using Comprehensive Meta-Analysis software (version 3.3.070 Biostat, Inc.). We calculated estimates of the combined prevalence of each variable by producing a forest plot was depicted for calculating the estimates of the combined prevalence of each variable. This study showed that the prevalence of L. pneumophila in clinical samples collected from patients was varied between 1.6 and 28.1%. The pooled prevalence of L. pneumophila in clinical samples was reported to 8.5%. Our systematic review and meta-analysis showed a considerable prevalence of L. pneumophila in countries located in the Middle East. Therefore, it should be considered in the identification of respiratory infections illness. It is also best to use both culture and molecular methods at the same time to diagnose the bacterium. Copyright ß 2021 Wolters Kluwer Health, Inc. All rights reserved. © 2022 Lippincott Williams and Wilkins. All rights reserved.
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