C1-Functionalization of 1,2,3,4-Tetrahydroisoquinolines (Thiqs)

C1-Functionalization of 1,2,3,4-Tetrahydroisoquinolines (Thiqs) Publisher

Tashrifi Z¹ ; Mohammadi Khanaposhtani M² ; Larijani B¹ ; Mahdavi M¹

Show Affiliations

1. Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Faculty of Fouman, College of Engineering, University of Tehran, Fouman, Iran

Source: Asian Journal of Organic Chemistry Published:2021

Abstract

1,2,3,4-tetrahydroisoquinoline (THIQ) and its derivatives possess a widespread biochemical, pharmaceutical and biological properties and they are the key building blocks in the structure of drugs and natural alkaloids. Accordingly, construction of multi-substituted and polycyclic THIQs through functionalization of THIQs at different positions especially at C1-position have come to the center of attraction in recent studies. In this review, we've focused on the classification of C1-functionalization of THIQs in the research articles from 2013 on, including a brief description of the reaction mechanisms for the synthesis of multi-substituted and polycyclic THIQs based on the type of substituents at the 1-position of the THIQ moiety. From this point of view, the main categories are C1-Functionalization and C1-Functionalization with annulation. © 2021 Wiley-VCH GmbH

Style	Citing Format
MLA	Tashrifi Z, et al.. "C1-Functionalization of 1,2,3,4-Tetrahydroisoquinolines (Thiqs)." Asian Journal of Organic Chemistry, vol. 10, no. 10, 2021, pp. 2421-2439.
APA	Tashrifi Z, Mohammadi Khanaposhtani M, Larijani B, Mahdavi M (2021). C1-Functionalization of 1,2,3,4-Tetrahydroisoquinolines (Thiqs). Asian Journal of Organic Chemistry, 10(10), 2421-2439.
Chicago	Tashrifi Z, Mohammadi Khanaposhtani M, Larijani B, Mahdavi M. "C1-Functionalization of 1,2,3,4-Tetrahydroisoquinolines (Thiqs)." Asian Journal of Organic Chemistry 10, no. 10 (2021): 2421-2439.
Harvard	Tashrifi Z et al. (2021) 'C1-Functionalization of 1,2,3,4-Tetrahydroisoquinolines (Thiqs)', Asian Journal of Organic Chemistry, 10(10), pp. 2421-2439.
Vancouver	Tashrifi Z, Mohammadi Khanaposhtani M, Larijani B, Mahdavi M. C1-Functionalization of 1,2,3,4-Tetrahydroisoquinolines (Thiqs). Asian Journal of Organic Chemistry. 2021;10(10):2421-2439.
BibTex	@article{ author = {Tashrifi Z and Mohammadi Khanaposhtani M and Larijani B and Mahdavi M}, title = {C1-Functionalization of 1,2,3,4-Tetrahydroisoquinolines (Thiqs)}, journal = {Asian Journal of Organic Chemistry}, volume = {10}, number = {10}, pages = {2421-2439}, year = {2021} }
RIS	TY - JOUR AU - Tashrifi Z AU - Mohammadi Khanaposhtani M AU - Larijani B AU - Mahdavi M TI - C1-Functionalization of 1,2,3,4-Tetrahydroisoquinolines (Thiqs) JO - Asian Journal of Organic Chemistry VL - 10 IS - 10 SP - 2421 EP - 2439 PY - 2021 ER -

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