Changes in the Epidemiology of Cutaneous Leishmaniasis in Northeastern Iran; [Kuzeydogu Iran’Da Kutanoz Leishmaniasisin Epidemiyolojisindeki Degisimler] Publisher Pubmed



Farash BRH^{1, 2, 3} ; Shamsian SAA¹ ; Mohajery M¹ ; Fata A^{1, 3} ; Sadabadi F¹ ; Berenji F¹ ; Mastroeni P⁴ ; Poustchi E¹ ; Moghaddas E¹ ; Sangani GS¹ ; Farnoosh G⁵ Show Affiliations
Source: Turkiye Parazitoloji Dergisi Published:2020

Abstract

The province of Khorasan-Razavi in the North East of Iran is an endemic area for anthroponotic cutaneous leishmaniasis (ACL caused mainly by Leishmania tropica) and zoonotic cutaneous leishmaniasis (ZCL caused mainly by Leishmania major). Based on clinical signs, some cities were considered as ACL foci while others were considered to be endemic for ZCL. This paper reviews studies performed on patients diagnosed with cutaneous leishmaniasis (CL) via the use of direct slide examination, ELISA, electrophoresis isoenzyme, RAPD PCR and PCR in Mashhad; the study also includes cases of CL in other cities of the Khorasan-Razavi province where only PCR used as a diagnostic tool. The data show that both Leishmania tropica and Leishmania major caused CL in most of the cities investigated. Our review shows that Leishmania major was found in areas where ACL is prevalent and Leishmania tropica was observed in areas with high incidence of ZCL. This distribution represents a major change in the epidemiological pattern of Leishmania in the Khorasan-Razavi province. © 2020, Galenos Publishing House. All rights reserved.