Identification of Etiologic Agents of the Pertussis-Like Syndrome in Children by Real-Time Pcr Method

Identification of Etiologic Agents of the Pertussis-Like Syndrome in Children by Real-Time Pcr Method Publisher Pubmed

Mahmoudi S¹ ; Banar M¹ ; Pourakbari B¹ ; Alavi HS² ; Eshaghi H² ; Ahari AA³ ; Mamishi S^{1, 2}

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1. Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Radiology, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

Source: Prague medical report Published:2018

Abstract

The aim of this study was to recognize the identity and frequency of etiologic agents of the pertussis-like syndrome in children < 2 years of age. A cross-sectional hospital-based study conducted from August 2014 to August 2015. All children < 2 years of age (n=100) who were suspected as pertussis infected were enrolled in this study and tested for Bordetella pertussis, adenovirus (Adv), respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and influenza virus A (INF-A) by real-time PCR technique. RSV was the most detected pathogen (20%), followed by B. pertussis (18%), Adv (16%), INF-A (11%), and hMPV (10%). Co-infection was observed in 8 patients (11%) and the combinations of RSV/INF-A (n=3, 4%), and AdV/B. pertussis (n=3, 4%) were more frequent. RSV, B. pertussis, and hMPV were more frequent pathogens among infants < 4 months of age. However, Adv and INF-A were more frequent pathogens among children > 6 months of age. In this study, RSV was the most frequent identified pathogen (n=20, 20%), followed by B. pertussis (n=18, 18%) and AdV (n=16, 16%). Pertussis was more frequent in spring (8%) and summer (6%). In addition, clinical symptoms of pertussis were the same as some viral pathogens, which can lead to misdiagnosis of infection. Therefore, diagnosis of pertussis should be established on the bases of both the clinical symptoms and the laboratory methods.

Style	Citing Format
MLA	Mahmoudi S, et al.. "Identification of Etiologic Agents of the Pertussis-Like Syndrome in Children by Real-Time Pcr Method." Prague medical report, vol. 119, no. 1, 2018, pp. 61-69.
APA	Mahmoudi S, Banar M, Pourakbari B, Alavi HS, Eshaghi H, Ahari AA, Mamishi S (2018). Identification of Etiologic Agents of the Pertussis-Like Syndrome in Children by Real-Time Pcr Method. Prague medical report, 119(1), 61-69.
Chicago	Mahmoudi S, Banar M, Pourakbari B, Alavi HS, Eshaghi H, Ahari AA, Mamishi S. "Identification of Etiologic Agents of the Pertussis-Like Syndrome in Children by Real-Time Pcr Method." Prague medical report 119, no. 1 (2018): 61-69.
Harvard	Mahmoudi S et al. (2018) 'Identification of Etiologic Agents of the Pertussis-Like Syndrome in Children by Real-Time Pcr Method', Prague medical report, 119(1), pp. 61-69.
Vancouver	Mahmoudi S, Banar M, Pourakbari B, Alavi HS, Eshaghi H, Ahari AA, et al.. Identification of Etiologic Agents of the Pertussis-Like Syndrome in Children by Real-Time Pcr Method. Prague medical report. 2018;119(1):61-69.
BibTex	@article{ author = {Mahmoudi S and Banar M and Pourakbari B and Alavi HS and Eshaghi H and Ahari AA and Mamishi S}, title = {Identification of Etiologic Agents of the Pertussis-Like Syndrome in Children by Real-Time Pcr Method}, journal = {Prague medical report}, volume = {119}, number = {1}, pages = {61-69}, year = {2018} }
RIS	TY - JOUR AU - Mahmoudi S AU - Banar M AU - Pourakbari B AU - Alavi HS AU - Eshaghi H AU - Ahari AA AU - Mamishi S TI - Identification of Etiologic Agents of the Pertussis-Like Syndrome in Children by Real-Time Pcr Method JO - Prague medical report VL - 119 IS - 1 SP - 61 EP - 69 PY - 2018 ER -

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