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Neuroprotective Effects of Probiotics Bacteria on Animal Model of Parkinson’S Disease Induced by 6-Hydroxydopamine: A Behavioral, Biochemical, and Histological Study Publisher Pubmed



Alipour Nosrani E1 ; Tamtaji OR2 ; Alibolandi Z3 ; Sarkar P3 ; Ghazanfari M2 ; Azami Tameh A3 ; Taghizadeh M2 ; Banikazemi Z2 ; Hadavi R4 ; Naderi Taheri M5, 6
Authors
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Authors Affiliations
  1. 1. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Department of Biochemistry and Student Research Committee, Semnan University of Medical School, Semnan, Iran
  5. 5. Nursing and Midwifery Care Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Deptartman of Community Health Geriatric Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Immunoassay and Immunochemistry Published:2021


Abstract

Parkinson’s disease (PD) is an age-associated, progressive, and common neurodegenerative disorder. It is characterized by dopaminergic neuron degeneration in the substantia nigra pars compacta. The involvement of oxidative stress, inflammation, and dysbiosis in PD has been confirmed and probiotics also have the ability to regulate the mentioned mechanisms. Here, we assessed probiotics supplementation effects on experimental model of PD. Thirty Male Wistar rats were divided into three groups for a 14-day treatment. It was shown that a mixture of probiotics containing Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus reuteri, and Lactobacillus fermentum could improve rotational behavior, cognitive function, lipid peroxidation, and neuronal damage in the group received probiotic supplementation compared to the other groups (P < 0001, P < .001, and P = .026, respectively). Taken together, these findings revealed that probiotics supplementation could be an appropriate complementary treatment for PD. © 2020 Taylor & Francis.
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