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Comparison of the Protective Effects of Melatonin and Silymarin Against Gentamicin-Induced Nephrotoxicity in Rats Publisher Pubmed



Ghaznavi H1 ; Mehrzadi S2 ; Dormanesh B3 ; Tabatabaei SMTH4 ; Vahedi H5 ; Hosseinzadeh A2 ; Pazokitoroudi H6 ; Rashidian A7
Authors
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Authors Affiliations
  1. 1. Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  2. 2. Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pediatric Nephrology, AJA University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pediatric Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Health Sciences Research Center, Department of Food and Nutrition, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Physiology Research Center (PRC), Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Evidence-Based Complementary and Alternative Medicine Published:2016


Abstract

This study compared the possible protective effects of silymarin and melatonin against gentamicin (GEN)-induced nephrotoxicity in rats. Rats were allocated to 6 groups: Group I, control group; Groups II and III, administered with silymarin or melatonin; Group IV, injected with GEN; and Groups V and VI, administered with silymarin or melatonin, and then injected with GEN. Compared with the rats in the control group, all rats injected with GEN significantly presented elevated levels of serum creatinine and urea that was accompanied by an increase in relative kidney weight, increase in renal reactive oxygen species (ROS) and malondialdehyde (MDA) levels, and reduction in renal glutathione (GSH) level and superoxide dismutase (SOD) activity. Silymarin and melatonin pretreatment significantly lowered the elevated serum urea and creatinine concentration, kidney weight, and renal ROS and MDA levels. In addition, silymarin and melatonin significantly enhanced renal GSH level and SOD activity. This study indicates that silymarin and melatonin can attenuate renal injury in rats treated with GEN possibly by reducing the ROS level. © 2015, © The Author(s) 2015.
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