Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran

Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran Publisher Pubmed

Younesi S¹ ; Amin MMT¹ ; Saadati P¹ ; Yazdani B² ; Jamali S¹ ; Modarresi MH³ ; Savad S³ ; Amidi S¹ ; Ghafourifard S⁴ ; Razmpoosh E^{5, 6} ; Yazarlou F³

Show Affiliations

1. Prenatal Screening Department of Nilou Laboratory, Tehran, Iran
2. Neonatal Screening Department of Nilou Laboratory, Tehran, Iran
3. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6. Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Source: Human Antibodies Published:2020

Abstract

OBJECTIVES: To evaluate the performance of the current national screening policy for Down syndrome (DS) in Iran and suggest a more efficient protocol with a wealth of a large series of first-trimester screening (FTS) data obtained from Nilou medical laboratory. To fulfill this aim, detection rate (DR), positive screening rate (PSR), false negative rate (FNR) and odds of being affected given a positive results (OAPR) were calculated at different cutoff risk. In the latest update of DS screening program in Iran, there is no place for intermediate group to be further investigated. Next, we proposed a novel parameter namely the ratio of fβ-hCG multiple of the median (MoM) value to PAPP-A MoM value to delicately categorize FTS results in a way that reduce FNR without imposing unnecessary anxious and extra money on most families. METHODS: The present investigation was conducted retrospectively on 197,210 pregnancies undergoing FTS for aneuploidies in Nilou medical laboratory, Tehran, Iran, from March 2015 to February 2016. RESULTS: Intermediate risk group is important as 23 out of 45 FN fell in the range 1:250 to 1:1100. By applying the proposed index, the ratio of fβ-hCG MoM to PAPP-A MoM and subsequent decision about NIPT, 8 out of 23 FN cases in intermediate group could be detected. CONCLUSION: Compared with the current policy, our novel proposed approach had better performance and could be applied by the Iran National Health Service to improve the screening program guideline. © 2020 - IOS Press and the authors. All rights reserved.

Experts (# of related papers)

Mohammad Hossein Modarressi (1)

Sedigheh Hantoushzadeh (1)

Style	Citing Format
MLA	Younesi S, et al.. "Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran." Human Antibodies, vol. 28, no. 3, 2020, pp. 203-210.
APA	Younesi S, Amin MMT, Saadati P, Yazdani B, Jamali S, Modarresi MH, Savad S, Amidi S, Ghafourifard S, Razmpoosh E, Yazarlou F (2020). Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran. Human Antibodies, 28(3), 203-210.
Chicago	Younesi S, Amin MMT, Saadati P, Yazdani B, Jamali S, Modarresi MH, Savad S, et al.. "Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran." Human Antibodies 28, no. 3 (2020): 203-210.
Harvard	Younesi S et al. (2020) 'Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran', Human Antibodies, 28(3), pp. 203-210.
Vancouver	Younesi S, Amin MMT, Saadati P, Yazdani B, Jamali S, Modarresi MH, et al.. Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran. Human Antibodies. 2020;28(3):203-210.
BibTex	@article{ author = {Younesi S and Amin MMT and Saadati P and Yazdani B and Jamali S and Modarresi MH and Savad S and Amidi S and Ghafourifard S and Razmpoosh E and Yazarlou F}, title = {Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran}, journal = {Human Antibodies}, volume = {28}, number = {3}, pages = {203-210}, year = {2020} }
RIS	TY - JOUR AU - Younesi S AU - Amin MMT AU - Saadati P AU - Yazdani B AU - Jamali S AU - Modarresi MH AU - Savad S AU - Amidi S AU - Ghafourifard S AU - Razmpoosh E AU - Yazarlou F TI - Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran JO - Human Antibodies VL - 28 IS - 3 SP - 203 EP - 210 PY - 2020 ER -

Style

Citing Format

MLA

Younesi S, et al.. "Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran." Human Antibodies, vol. 28, no. 3, 2020, pp. 203-210.

APA

Younesi S, Amin MMT, Saadati P, Yazdani B, Jamali S, Modarresi MH, Savad S, Amidi S, Ghafourifard S, Razmpoosh E, Yazarlou F (2020). Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran. Human Antibodies, 28(3), 203-210.

Chicago

Younesi S, Amin MMT, Saadati P, Yazdani B, Jamali S, Modarresi MH, Savad S, et al.. "Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran." Human Antibodies 28, no. 3 (2020): 203-210.

Harvard

Younesi S et al. (2020) 'Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran', Human Antibodies, 28(3), pp. 203-210.

Vancouver

Younesi S, Amin MMT, Saadati P, Yazdani B, Jamali S, Modarresi MH, et al.. Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran. Human Antibodies. 2020;28(3):203-210.

BibTex

@article{ author = {Younesi S and Amin MMT and Saadati P and Yazdani B and Jamali S and Modarresi MH and Savad S and Amidi S and Ghafourifard S and Razmpoosh E and Yazarlou F}, title = {Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran}, journal = {Human Antibodies}, volume = {28}, number = {3}, pages = {203-210}, year = {2020} }

RIS

TY - JOUR
AU - Younesi S
AU - Amin MMT
AU - Saadati P
AU - Yazdani B
AU - Jamali S
AU - Modarresi MH
AU - Savad S
AU - Amidi S
AU - Ghafourifard S
AU - Razmpoosh E
AU - Yazarlou F
TI - Fine-Tuning of Routine Combined First- Trimester Screening: The Ratio of Serum-Free- Beta-Human Chorionic Gonadotropin (Fβ Β-Hcg) to Pregnancy-Associated Plasma Protein-A (Papp-A) Could Improve Performance of Down Syndrome Screening Program, a Retrospective Cohort Study in Iran
JO - Human Antibodies
VL - 28
IS - 3
SP - 203
EP - 210
PY - 2020
ER -

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