While Urine and Plasma Decorin Remain Unchanged in Prostate Cancer, Prostatic Tissue Decorin Has a Prognostic Value

While Urine and Plasma Decorin Remain Unchanged in Prostate Cancer, Prostatic Tissue Decorin Has a Prognostic Value Publisher Pubmed

Rezaie R^{1, 2} ; Falakian Z^{1, 2} ; Mazloomzadeh S³ ; Ayati M⁴ ; Morakabati A⁵ ; Dastjerdan MRT⁶ ; Zare M⁷ ; Moghimi M⁸ ; Shahani T^{1, 2} ; Biglari A^{1, 2}

Show Affiliations

1. Department of Genetics and Molecular Medicine, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, 45139-56111, Iran
2. Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences (ZUMS), Zanjan, 45139-56111, Iran
3. Department of Epidemiology and Statistics, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, 45139-56111, Iran
4. Uro-Oncology Research Center, Tehran University of Medical Sciences (TUMS), Tehran, 1419733141, Iran
5. Molecular Pathology Department of Mehr General Hospital, Tehran, 1415755411, Iran
6. Urology Department of Farabi General Hospital, Mashhad, 9178686918, Iran
7. Molecular Pathology Department of 17-Shahrivar General Hospital, Mashhad, 91746, Iran
8. Department of Hemathology Onchology, Zanjan University of Medical Sciences (ZUMS), Zanjan, 45139-56111, Iran

Source: Iranian Biomedical Journal Published:2020

Abstract

Background: Numerous studies confirmed significant decrease in tissue DCN expression is associated to tumor progression and metastasis in certain types of cancer including PC. However, the potential prognostic value of tissue DCN in PC has not yet been investigated. Methods: A total number of 40 PC and 42 patients with BPH were investigated for the expression levels of DCN in their prostatic tissues using real-rime qPCR and immunohistochemical analyses. Urinary and plasma DCN levels were also measured by ELISA. Results: Despite no significant changes in the mean of urine and plasma DCN concentrations between the two study groups, tissue DCN mRNA was found to be 5.5fold lower in cancer than BPH (p = 0.0001). Similarly, the stained DCN levels appeared significantly lower in cancer patients with higher Gleason Scores (8 and 9, n = 6) than those with lower Gleason Scores (6 and 7, n = 26), with a p value of 0.049. Conclusion: Here, we report, for the first time, that urine and plasma DCN does not seem to have a diagnostic value in PC, while tissue DCN could potentially be used as a prognostic marker in PC. © 2020, Pasteur Institute of Iran. All Rights Reserved.

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Style	Citing Format
MLA	Rezaie R, et al.. "While Urine and Plasma Decorin Remain Unchanged in Prostate Cancer, Prostatic Tissue Decorin Has a Prognostic Value." Iranian Biomedical Journal, vol. 24, no. 4, 2020, pp. 229-235.
APA	Rezaie R, Falakian Z, Mazloomzadeh S, Ayati M, Morakabati A, Dastjerdan MRT, Zare M, Moghimi M, Shahani T, Biglari A (2020). While Urine and Plasma Decorin Remain Unchanged in Prostate Cancer, Prostatic Tissue Decorin Has a Prognostic Value. Iranian Biomedical Journal, 24(4), 229-235.
Chicago	Rezaie R, Falakian Z, Mazloomzadeh S, Ayati M, Morakabati A, Dastjerdan MRT, Zare M, Moghimi M, Shahani T, Biglari A. "While Urine and Plasma Decorin Remain Unchanged in Prostate Cancer, Prostatic Tissue Decorin Has a Prognostic Value." Iranian Biomedical Journal 24, no. 4 (2020): 229-235.
Harvard	Rezaie R et al. (2020) 'While Urine and Plasma Decorin Remain Unchanged in Prostate Cancer, Prostatic Tissue Decorin Has a Prognostic Value', Iranian Biomedical Journal, 24(4), pp. 229-235.
Vancouver	Rezaie R, Falakian Z, Mazloomzadeh S, Ayati M, Morakabati A, Dastjerdan MRT, et al.. While Urine and Plasma Decorin Remain Unchanged in Prostate Cancer, Prostatic Tissue Decorin Has a Prognostic Value. Iranian Biomedical Journal. 2020;24(4):229-235.
BibTex	@article{ author = {Rezaie R and Falakian Z and Mazloomzadeh S and Ayati M and Morakabati A and Dastjerdan MRT and Zare M and Moghimi M and Shahani T and Biglari A}, title = {While Urine and Plasma Decorin Remain Unchanged in Prostate Cancer, Prostatic Tissue Decorin Has a Prognostic Value}, journal = {Iranian Biomedical Journal}, volume = {24}, number = {4}, pages = {229-235}, year = {2020} }
RIS	TY - JOUR AU - Rezaie R AU - Falakian Z AU - Mazloomzadeh S AU - Ayati M AU - Morakabati A AU - Dastjerdan MRT AU - Zare M AU - Moghimi M AU - Shahani T AU - Biglari A TI - While Urine and Plasma Decorin Remain Unchanged in Prostate Cancer, Prostatic Tissue Decorin Has a Prognostic Value JO - Iranian Biomedical Journal VL - 24 IS - 4 SP - 229 EP - 235 PY - 2020 ER -

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