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Catalytic and Non-Catalytic Amidation of Carboxylic Acid Substrates Publisher Pubmed



Pedrood K1 ; Bahadorikhalili S2 ; Lotfi V2 ; Larijani B1 ; Mahdavi M1
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Chemistry, College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran

Source: Molecular Diversity Published:2022


Abstract

Abstract: The present review offers an apt summary of amide bond formation with carboxylic acid substrates by taking advantage of several methods. Carboxamides can be regarded as a substantial part of organic and medicinal chemistry due to their utility in synthesizing peptides, lactams, and more than 25% of familiar drugs. Moreover, they play a leading role in the synthesis of bioactive products with anticancer, antifungal, and antibacterial properties. The data are arranged based on the type and amount of reagents used to conduct amidation and are also divided into the following categories: catalytic amidation of carboxylic acids, non-catalytic amidation, and transamidation. Graphic abstract: [Figure not available: see fulltext.]. © 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG.