Tehran University of Medical Sciences

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Carboxylesterases Publisher



Mojtabavi S1 ; Amin M2
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 Published:2023


Abstract

Carboxylesterases (CESs) belong to the α/β-hydrolase superfamily, responsible for the carboxylester hydrolysis into carboxylic acid and alcohol. CESs are crucial in the biomedical field. They contribute to the delivery of various drugs and conversion of pro-carcinogens into carcinogens. CESs are isolated from diverse sources, such as fungi, bacteria, algae, plants, humans, and animals. Carboxylesterases detoxify organophosphates through a scavenging mechanism, while pyrethroids and carbamates are detoxified through hydrolysis. Carboxylesterases are expressed in different tissues such as gut epithelia, lungs, kidney and liver with various biological activities. © 2024 Elsevier Inc. All rights reserved.