Synthesis, Characterization, and in Vitro Evaluation of the Starch-Based Α-Amylase Responsive Hydrogels Publisher Pubmed



Davoodimonfared P¹ ; Akbaribirgani S^{1, 2} ; Mohammadi S^{3, 4} ; Kazemi F⁵ ; Nikfarjam N⁵ ; Nikbakht M^{3, 4} ; Mousavi SA^{3, 4} Show Affiliations
Source: Journal of Cellular Physiology Published:2021

Abstract

Controlled-release drug delivery systems are promising platforms in medicine. Among various types of material in drug delivery, hydrogels are interesting ones. They are water-soluble and tissue compatible polymers with a high capacity to carry and release drugs in a controllable manner. In this study, we introduce the synthesis, characterization, and application of an α-amylase responsive hydrogel in controlled drug delivery. The newly synthesized starch-based hydrogels structurally characterized by means of Fourier-transform infrared spectroscopy and scanning electron microscopy. A proapoptotic drug, doxorubicin, was loaded into the hydrogels and the controlled release of the drug was assessed in the presence of α-amylase and ultimately it was evaluated to controlled-drug release in vitro and subsequently in killing cancer cells. Our results highlight the effectiveness of temporal drug delivery using α-amylase responsive hydrogels in killing cancer cells. © 2020 Wiley Periodicals LLC