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Adverse Events Following Immunization (Aefi) in Children Under 7- Year of Age During 2014 in Hamedan Province, Iran Publisher



Khazaei S1 ; Rezaeian S2 ; Razani M3 ; Zahiri A4 ; Saatchi M5 ; Khazaei S1 ; Hafshjani AM7 ; Darvishi M8
Authors
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Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
  3. 3. Faculty Member of Nursing Department, Broujerd Branch, Islamic Azad University, Broujerd, Iran
  4. 4. Expert of Public Health, Deputy of Health, Hamadan University of Medical Sciences, Hamadan, Iran
  5. 5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Expert of Operating Room, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  7. 7. Social Determinants in Health Promotion Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  8. 8. Lorestan University of Medical Sciences, Khorramabad, Iran

Source: International Journal of Pediatrics Published:2016


Abstract

Background: The surveillance of adverse events following immunization (AEFI) is essential to improve high standard of vaccine safety, and maintain public trust in immunization programs. This study aimed to determine the AEFI and their related factors in children. Materials and Methods: This cross-sectional study including all children under 7- year of age, in Hamadan Province, the West of Iran, in 2014. All of the AEFI related with Bacille Calmette-Guerin (BCG), Diphtheria, Pertussis, and Tetanus (DPT), Measles, Mumps, and Rubella (MMR) vaccines were obtained from the documented record-based by Health Centers, in Hamadan province. Results: From a total of 239,204 doses administered, 284 AEFI were notified (11.8 per 10,000 doses). The proportion of AEFI was more frequently reported from Health Houses than Health Centers (60.2 vs. 37.0, P < 0.05). The most frequently AEFI reported was lymphadenitis (31.4%), followed by hyperpyrexia (17%), and severe local reaction (13.5%). Most frequently AEFI reported were related to vaccination reaction (74.7%) and programmatic errors (12.7%). Also, for incidence of lymphadenitis, the overall median time from vaccination to adverse event was 2 days (IQR: 2-15) and the highest median time was 15 days (IQR: 15-571). Conclusion: Our study shown, an increased risk of AEFI in the region and point out that the programmatic error still needs to be considered. Accordingly, the more activities need to be consolidated to reduce the adverse effect. This study assessed the different aspects of AEFI which may help policymakers to improve the immunization programs.
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