Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Glatiramer Acetate Treatment Inhibits Inflammatory Responses and Improves Survival in a Mice Model of Cecal Ligation and Puncture-Induced Sepsis Publisher Pubmed



Maleki E1 ; Sheibani M2, 3 ; Nezamoleslami S2, 3 ; Dehpour AR2, 3 ; Takzaree N4 ; Shafaroodi H2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Faculty of Pharmacy and Pharmaceutical Science, Islamic Azad University of Medical Science, Tehran, Iran
  2. 2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran
  3. 3. Experimental Medicine Research Center, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran
  4. 4. Department of Anatomy & Histology, School of Medicine, Tehran University of Medical Science, Tehran, Iran

Source: Journal of Basic and Clinical Physiology and Pharmacology Published:2022


Abstract

Objectives: Sepsis is a clinical crisis which has been considered as one of the important causes of mortality across the world. We hypothesized that modulation of hyper-inflammatory phase of sepsis pathophysiology can lead to protective effects on survival outcome. Glatiramer acetate (GA) is a neuroprotective drug commonly used in multiple sclerosis (MS). GA is characterized by immunom activity via regulation of innate and adaptive immunity. This study was designed to evaluate the acute treatment with GA on initial inflammatory response-induced mortality in septic mice. Methods: Cecal ligation and puncture (CLP) model was operated on male mice as a model of Polymicrobial sepsis. GA was administrated intraperitoneally after the sepsis induction at doses of 0.5, 1, and 2 mg/kg in three treatment groups. To investigate the effect of GA on short-term survival, septic mice were observed during 72 h after CLP. Serum levels of TNF-α, IL-1β, and IL-6 as pro-inflammatory cytokines and also IL-10 as a critical anti-inflammatory cytokine were analysed. To consider sepsis-induced acute kidney injury, renal functional biomarkers and histopathological changes was assessed. Results: GA treatment significantly improved survival rate at doses of 1, and 2 mg/kg. Survival improvement was accompanied by remarkable reduction in the pro-inflammatory cytokines and enhanced production of IL-10. GA showed to have protective effects on renal function as well. Conclusions: Immunomodulatory and anti-inflammatory properties of GA resulted in increase in survival rate and decrease in inflammatory markers in mice model of cecal ligation and puncture-induced sepsis. © 2021 Walter de Gruyter GmbH, Berlin/Boston.
Related Docs
1. A Comprehensive Systematic Review of the Therapeutic Effects and Mechanisms of Action of Quercetin in Sepsis, Phytomedicine (2021)
2. Nano-Curcumin Supplementation in Critically Ill Patients With Sepsis: A Randomized Clinical Trial Investigating the Inflammatory Biomarkers, Oxidative Stress Indices, Endothelial Function, Clinical Outcomes and Nutritional Status, Food and Function (2022)
3. Global Mortality Associated With 33 Bacterial Pathogens in 2019: A Systematic Analysis for the Global Burden of Disease Study 2019, The Lancet (2022)
4. Efficacy of Dietary Supplements on Mortality and Clinical Outcomes in Adults With Sepsis and Septic Shock: A Systematic Review and Network Meta-Analysis, Clinical Nutrition (2024)
Experts (# of related papers)
View all Related Experts
Farzad Kompani (1)
Masoud Mohammad Pour (1)