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The Promising Role of Monoclonal Antibodies for Gastric Cancer Treatment Publisher Pubmed



Afshari F1 ; Soleymanjahi S2, 3, 4 ; Keshavarzfathi M1, 5, 6 ; Roviello G7, 8 ; Rezaei N6, 9, 10
Authors
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Authors Affiliations
  1. 1. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  2. 2. Digestive Diseases Research Cores Center, Division of Gastroenterology, School of Medicine, Washington University, St. Louis, United States
  3. 3. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), St. Louis, United States
  4. 4. Cancer Research Center, Cancer Institute of Iran, Tehran, Iran
  5. 5. Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Medical Oncology Unit, Department of Oncology, San Donato Hospital, Via Nenni 20, Arezzo, Italy
  8. 8. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Arezzo, Italy
  9. 9. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Sheffield, United Kingdom

Source: Immunotherapy Published:2019


Abstract

Gastric cancer (GC) is the second leading cause of cancer-related death world-wide. Despite improvements in prevention, early detection and various therapeutic options, the prognosis is still poor. GC is often diagnosed at an advanced stage with survivals less than 1 year. Chemotherapy as the mainstay of treatment in advanced stage is not of notable advantages, underlining the need for novel more effective therapeutic options. Based on current knowledge of molecular and cellular mechanisms, a number of novel biologic approaches such as monoclonal antibodies have been recently introduced for cancer treatment that mainly affect the immune system or target signaling pathways playing role in cancer and metastasis development. In this review, various monoclonal antibodies for GC therapy were explained. © 2019 2019 Future Medicine Ltd.
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