Increased Level of Cathelicidin (Ll-37) in Vitiligo: Possible Pathway Independent From Vitamin D Receptor Gene Polymorphism

Increased Level of Cathelicidin (Ll-37) in Vitiligo: Possible Pathway Independent From Vitamin D Receptor Gene Polymorphism Publisher Pubmed

Atazadeh F¹ ; Fazeli Z² ; Vahidnezhad H^{3, 4} ; Namazi N¹ ; Younespour S⁵ ; Youssefian L^{3, 4} ; Abdollahimajd F^{1, 6} ; Uitto J^{3, 4}

Show Affiliations

1. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States
4. Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA, United States
5. Dentistry Research institute, Tehran University of Medical Sciences, Tehran, Iran
6. Clinical Research Development Unit, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Experimental Dermatology Published:2020

Abstract

Vitiligo is a multifactorial skin disease with established role of genetics and autoimmunity in its pathogenesis. Vitamin D receptor (VDR) polymorphisms have been suggested to correlate with risk of vitiligo in some ethnic populations. On the other hand, cathelicidin, one of the innate immune system components, has a role in development of some chronic skin diseases and VDR regulates the expression of cathelicidin. We aimed to determine the plasma level of cathelicidin and its association with the VDR gene polymorphisms as well as plasma vitamin D level in patients with vitiligo. Ninety vitiligo patients and 90 non-vitiligo controls participated in this study. Blood levels of 25(OH) vitamin D and cathelicidin were determined with ELISA. Genotyping for VDR polymorphisms (ApaI, TaqI, FokI and BsmI) was done with RFLP-PCR method. Mean blood level of cathelicidin was significantly higher in vitiligo patients as compared to controls (P <.0001). Mean blood level of vitamin D was significantly lower in patients than controls (P =.01). Statistically significant differences were not observed for both genotype and allele frequencies of BsmI, ApaI and TaqI polymorphisms. There was a borderline increased risk of vitiligo in over-dominant model of FokI polymorphism with OR = 1.8 and P =.051. Our findings was suggestive of the potential role of cathelicidin in the pathogenesis of vitiligo; however, future evaluations are needed to determine its precise mechanism. Genetic study of VDR gene polymorphism was suggestive of increased risk of vitiligo in association with a FokI polymorphism in Iranian population. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Style	Citing Format
MLA	Atazadeh F, et al.. "Increased Level of Cathelicidin (Ll-37) in Vitiligo: Possible Pathway Independent From Vitamin D Receptor Gene Polymorphism." Experimental Dermatology, vol. 29, no. 12, 2020, pp. 1176-1185.
APA	Atazadeh F, Fazeli Z, Vahidnezhad H, Namazi N, Younespour S, Youssefian L, Abdollahimajd F, Uitto J (2020). Increased Level of Cathelicidin (Ll-37) in Vitiligo: Possible Pathway Independent From Vitamin D Receptor Gene Polymorphism. Experimental Dermatology, 29(12), 1176-1185.
Chicago	Atazadeh F, Fazeli Z, Vahidnezhad H, Namazi N, Younespour S, Youssefian L, Abdollahimajd F, Uitto J. "Increased Level of Cathelicidin (Ll-37) in Vitiligo: Possible Pathway Independent From Vitamin D Receptor Gene Polymorphism." Experimental Dermatology 29, no. 12 (2020): 1176-1185.
Harvard	Atazadeh F et al. (2020) 'Increased Level of Cathelicidin (Ll-37) in Vitiligo: Possible Pathway Independent From Vitamin D Receptor Gene Polymorphism', Experimental Dermatology, 29(12), pp. 1176-1185.
Vancouver	Atazadeh F, Fazeli Z, Vahidnezhad H, Namazi N, Younespour S, Youssefian L, et al.. Increased Level of Cathelicidin (Ll-37) in Vitiligo: Possible Pathway Independent From Vitamin D Receptor Gene Polymorphism. Experimental Dermatology. 2020;29(12):1176-1185.
BibTex	@article{ author = {Atazadeh F and Fazeli Z and Vahidnezhad H and Namazi N and Younespour S and Youssefian L and Abdollahimajd F and Uitto J}, title = {Increased Level of Cathelicidin (Ll-37) in Vitiligo: Possible Pathway Independent From Vitamin D Receptor Gene Polymorphism}, journal = {Experimental Dermatology}, volume = {29}, number = {12}, pages = {1176-1185}, year = {2020} }
RIS	TY - JOUR AU - Atazadeh F AU - Fazeli Z AU - Vahidnezhad H AU - Namazi N AU - Younespour S AU - Youssefian L AU - Abdollahimajd F AU - Uitto J TI - Increased Level of Cathelicidin (Ll-37) in Vitiligo: Possible Pathway Independent From Vitamin D Receptor Gene Polymorphism JO - Experimental Dermatology VL - 29 IS - 12 SP - 1176 EP - 1185 PY - 2020 ER -

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