The Correlation of Health-Related Quality of Life With Cystic Fibrosis Severity Markers in Chest Ct Scan and 6-Minute Walk Test: A Cross-Sectional Study Publisher Pubmed



Modaresi M¹ ; Roshanzamir Z¹ ; Shirzadi R¹ Show Affiliations
Source: Indian Journal of Pediatrics Published:2022

Abstract

Objective: To investigate the correlation between severity of lung disease determined by chest computed tomography (CT) and 6-min walk test (6MWT) with health-related quality of life (HRQoL) score in cystic fibrosis (CF) patients. Methods: This cross-sectional study evaluated 76 CF patients referred to CF Clinic, aged 7–14 y. Subjects were asked to complete Pediatric quality of life (PedsQL4.0) forms, during their outpatient visits to determine their HRQoL score. Patients’ lung disease severity was quantified by Bhalla score determined by the child’s chest CT and their 6MWT. These three variables were then analyzed to determine whether there is correlation between HRQoL with severity of lung disease. Results: The mean distance of patients 6MWT score was 447.4 ± 81.4 m. There was a positive correlation between distance and HRQoL score in total, social, school and emotional function (p < 0.05). However, in physical function the correlation lacked significance (p = 0.07). Patients with a Bhalla score of less than 15 were older than patients with a Bhalla score of more than 15 (p < 0.001). Physical, emotional, social, school, and total function scores were significantly lower in patients with Bhalla score less than 15, compared to those with Bhalla score greater than 15 (p < 0.05). Conclusions: The correlation among Bhalla score on CT scan, 6-min walk test, and HRQoL indicates that pulmonary disease has a clear impact on the quality of life of CF patients. HRQoL can be used in the care program of children with CF. © 2021, Dr. K C Chaudhuri Foundation.