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Comparison of the Effects of Ultrasound in a Repetitive Mode and Acoustically Active Lipospheres in the Presence of Doxorubicin on Breast Adenocarcinoma Publisher Pubmed



Soleimani H1 ; Abdolmaleki P2 ; Mokhtaridizaji M3 ; Toliat T4 ; Tavasoly A5
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics and Physiology, School of Medical Sciences, Arak University of Medical Science, Arak, Iran
  2. 2. Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Medical Physics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  4. 4. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pathology, Faculty of Veterinary Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Cancer Research and Therapeutics Published:2020


Abstract

Purpose: We want to compare the synergistic effect of low-intensity, dual-frequency (dual) ultrasound (US), applied in a repetitive sonication mode, and acoustically active lipospheres (AALs) containing doxorubicin (DOX) in a murine model (Balb/C). Subjects and Methods: The tumor-bearing mice were divided into nine groups, namely two untreated groups (control and sham), and seven experimental groups, including treated with dual-frequency US (150 kHzcontinuous + 1MHzpulse), triple exposure (3×30min) dual-frequency US, DOX (2 mg/kg intravenous), DOX in combination with single exposure (30 min) to dual-frequency US (drug + dual), DOX in combination with triple (3 × 30 min) exposure to dual-frequency US (drug + dual [REP]), AALs containing the drug-loaded (AAL), and a group receiving AAL in combination with single exposure (30 min) dual-frequency US (AAL + dual), respectively. Results: The effectiveness of DOX on tumor growth was enhanced by a factor of three when combined with the triple exposures of dual US (drug + dual [REP]). This combination protocol further increased the times needed for each tumor to 2 and 7 times its initial volume, respectively by 94% and 36% compared to the drug group. During the 30 days, following the treatment of tumors, the relative volume of tumors in AAL group was 118% less than that of the drug group. The survival rate of the groups treated with drug and AAL + dual was increased by 78.7% and 167% compared with sham, respectively. Conclusion: Although as a short treatment, a major improvement in treatment was observed by (drug + dual [REP]) compared with other treatments, the AAL + dual treatment compared with (drug + dual [REP]) showed an increase in the survival rates, hence more preferable over long periods. © 2020 Journal of Cancer Research and Therapeutics | Published by Wolters Kluwer - Medknow.
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