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The Outcomes of Marginal Donor Hearts Compared With Ideal Donors: A Single-Center Experience in Iran Publisher



Shakerian B1 ; Dehghani S2, 3 ; Ashraf H4 ; Karbalai S5 ; Soleimani A5 ; Rezaeefar A5 ; Shajari Z5 ; Hekmat H6 ; Latifi M2 ; Sadatnaseri A5
Authors
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Authors Affiliations
  1. 1. Department of Cardiovascular Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Organ Procurement Unit, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cardiac Primary Prevention Research Center (CPPRC), Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Cardiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Cardiology, Ziaeian Hospital, School of Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran

Source: Korean Journal of Transplantation Published:2022


Abstract

Background: Heart transplantation has been considered the gold-standard treatment for patients with end-stage heart failure. This study assessed the survival outcomes of marginal donor hearts compared with ideal donor hearts in Iran. Methods: This retrospective study is based on the follow-up data of heart donors and recipients in the Sina Hospital Organ Procurement Unit. Among the 93 participants, 75 were categorized as ideal donors (group A) and 18 as marginal donors (group B). Group C included heart recipients who received a standard organ, and group D included heart recipients who received a marginal one. To analyze differences in patient characteristics among the groups, posttransplant heart survival was assessed in all groups. All data were obtained from the hospital records. Results: The mean age of the donors was 26.27±11.44 years (median age, 28 years). The marginal age showed a significant association with donor age. The age of recipients had a significant effect on survival days in the ideal group. Most patients survived for at least 1 year, with a median of 645 days in recipients from marginal donors and 689 days in recipients from ideal donors. Conclusions: Considering the lack of organ availability in Iran, it may be possible to use marginal donors for marginal recipients, therefore reducing the number of people on the waitlist. We also recommend establishing a national marginal donor system specifically for Iranian patients to extend the donor pool. © 2022 Universidad Politecnica Salesiana. All rights reserved.