The Effects of Lower Cd34 Yields After Lowe Dose G-Csf Induction on Long-Term Autologous Stem Cell Transplantation Outcome: A Single Center Study Publisher Pubmed



Vaezi M^{1, 2, 3} ; Shakouri M¹ ; Souri M¹ ; Setaredan MA¹ ; Mossavi SA^{1, 2, 3} ; Mohammadi S^{1, 2, 3} ; Alimoghaddam K^{1, 2, 3} ; Ghavamzadeh A^{1, 2, 3} Show Affiliations
Source: Transfusion and Apheresis Science Published:2018

Abstract

Peripheral blood stem cell transplantation (PBSCT) is an effective treatment for hematological malignancies. Mobilization of peripheral blood stem cells performs in different ways among transplantation centers. Since the Effects of lower CD34+ cells dose after low dose G-CSF induction on autologous stem cell transplantation outcomes are not studied much, so this study was performed for this purpose. 735 autologous stem cell transplanted patients with diagnoses of multiple myeloma (n = 330), Hodgkin lymphoma (n = 200), non-Hodgkin lymphoma (n = 129), acute myeloid leukemia (n = 54) and solid tumors (n = 22) were retrospectively evaluated. G-CSF was administered at the dose of 5 μg/kg/day during mobilization and all patients except acute myeloid leukemia received 10 μg/kg/day on the last day. Peripheral blood stem cells were harvested in one session for all patients. The amount of injected CD34+ cells/kg for patients were divided and studied in four groups: <0.5 × 106 (n = 36), 0.5–1.0 × 106, (n = 132), 1.0–2.0 × 106 (n = 226) and >2.0 × 106 (n = 305). The median time of follow up was 26.9 months. The amount of CD34+ cells dose were a significant predictor of platelet engraftment, but overall survival, relapse-free survival and also relapse rate was not associated with cells yield. More platelet transfusion (P = 0.003) and antibiotics prescription (P = 0.001) in transplanted patients with lower CD34 cells dose should be balanced with risks of higher G-CSF doses administration and also its side effects. Our results declare that lower CD34 yields after lowe dose G-CSF induction are probably not a troublesome issue affecting transplantation outcomes. © 2018 Elsevier Ltd