A Rapid Review of Influential Factors and Appraised Solutions on Organ Delineation Uncertainties Reduction in Radiotherapy

A Rapid Review of Influential Factors and Appraised Solutions on Organ Delineation Uncertainties Reduction in Radiotherapy Publisher Pubmed

Sadeghi S¹ ; Siavashpour Z² ; Sadr AV³ ; Farzin M^{4, 5} ; Sharp R⁶ ; Gholami S⁷

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1. Department of Nuclear Physics, Faculty of Sciences, University of Mazandaran, Babolsar, Iran
2. Department of Radiation Oncology, Shohada-e Tajrish Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Departement de Physique Theorique, Center for Astroparticle Physics, Universite de Geneve, Geneva, Switzerland
4. Radiation Oncology Research Center (RORC), Tehran University of Medical Science, Tehran, Iran
5. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, NV, United States
7. Radiotherapy Oncology Department, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Biomedical Physics and Engineering Express Published:2021

Abstract

Background and purpose. Accurate volume delineation plays an essential role in radiotherapy. Contouring is a potential source of uncertainties in radiotherapy treatment planning that could affect treatment outcomes. Therefore, reducing the degree of contouring uncertainties is crucial. The role of utilized imaging modality in the organ delineation uncertainties has been investigated. This systematic review explores the influential factors on inter-and intra-observer uncertainties of target volume and organs at risk (OARs) delineation focusing on the used imaging modality for these uncertainties reduction and the reported subsequent histopathology and follow-up assessment. Methods and materials. An inclusive search strategy has been conducted to query the available online databases (Scopus, Google Scholar, PubMed, and Medline). ‘Organ at risk’, ‘target’, ‘delineation’, ‘uncertainties’, ‘radiotherapy’ and their relevant terms were utilized using every database searching syntax. Final article extraction was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Included studies were limited to the ones published in English between 1995 and 2020 and that just deal with computed tomography (CT) and magnetic resonance imaging (MRI) modalities. Results. A total of 923 studies were screened and 78 were included of which 31 related to the prostate 20 to the breast, 18 to the head and neck, and 9 to the brain tumor site. 98% of the extracted studies performed volumetric analysis. Only 24% of the publications reported the dose deviations resulted from variation in volume delineation Also, heterogeneity in studied populations and reported geometric and volumetric parameters were identified such that quantitative synthesis was not appropriate. Conclusion. This review highlightes the inter- and intra-observer variations that could lead to contouring uncertainties and impede tumor control in radiotherapy. For improving volume delineation and reducing inter-observer variability, the implementation of well structured training programs, homogeneity in following consensus and guidelines, reliable ground truth selection, and proper imaging modality utilization could be clinically beneficial. © 2021 IOP Publishing Ltd.

Style	Citing Format
MLA	Sadeghi S, et al.. "A Rapid Review of Influential Factors and Appraised Solutions on Organ Delineation Uncertainties Reduction in Radiotherapy." Biomedical Physics and Engineering Express, vol. 7, no. 5, 2021, pp. -.
APA	Sadeghi S, Siavashpour Z, Sadr AV, Farzin M, Sharp R, Gholami S (2021). A Rapid Review of Influential Factors and Appraised Solutions on Organ Delineation Uncertainties Reduction in Radiotherapy. Biomedical Physics and Engineering Express, 7(5), -.
Chicago	Sadeghi S, Siavashpour Z, Sadr AV, Farzin M, Sharp R, Gholami S. "A Rapid Review of Influential Factors and Appraised Solutions on Organ Delineation Uncertainties Reduction in Radiotherapy." Biomedical Physics and Engineering Express 7, no. 5 (2021): -.
Harvard	Sadeghi S et al. (2021) 'A Rapid Review of Influential Factors and Appraised Solutions on Organ Delineation Uncertainties Reduction in Radiotherapy', Biomedical Physics and Engineering Express, 7(5), pp. -.
Vancouver	Sadeghi S, Siavashpour Z, Sadr AV, Farzin M, Sharp R, Gholami S. A Rapid Review of Influential Factors and Appraised Solutions on Organ Delineation Uncertainties Reduction in Radiotherapy. Biomedical Physics and Engineering Express. 2021;7(5):-.
BibTex	@article{ author = {Sadeghi S and Siavashpour Z and Sadr AV and Farzin M and Sharp R and Gholami S}, title = {A Rapid Review of Influential Factors and Appraised Solutions on Organ Delineation Uncertainties Reduction in Radiotherapy}, journal = {Biomedical Physics and Engineering Express}, volume = {7}, number = {5}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Sadeghi S AU - Siavashpour Z AU - Sadr AV AU - Farzin M AU - Sharp R AU - Gholami S TI - A Rapid Review of Influential Factors and Appraised Solutions on Organ Delineation Uncertainties Reduction in Radiotherapy JO - Biomedical Physics and Engineering Express VL - 7 IS - 5 SP - EP - PY - 2021 ER -

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Abstract