Staging of Cognitive Impairment in Parkinson’S Disease: Validity of Quick Dementia Rating System

Staging of Cognitive Impairment in Parkinson’S Disease: Validity of Quick Dementia Rating System Publisher Pubmed

Mahmoudi Asl A^{1, 8} ; Mehdizadeh M^{2, 9} ; Raeesi Roudbari P³ ; Mehdizadeh H⁴ ; Habibi SA⁵ ; Niazi Khatoon J⁶ ; Taghizadeh G⁷

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1. Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran
2. Department of Neurosciences, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
3. Department of Occupational Therapy, School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Neurosciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Neurology, Rasoul Akram Hospital, Iran University of Medical Science, Tehran, Iran
6. Department of Occupational Therapy, School of Allied Medicine, Mazandaran University of Medical Sciences, Sari, Iran
7. Rehabilitation Research Center, Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran
8. Neuroscience research unit, Institute for Biomedical Research of Salamanca, University of Salamanca, Salamanca, Spain
9. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Disability and Rehabilitation Published:2022

Abstract

Purpose: This study aimed to investigate the ability of the Quick Dementia Rating System (QDRS) to discriminate patients with PD who have mild cognitive impairment from those without cognitive impairment and those with dementia. Method: A total of 105 patients with PD were classified as without cognitive impairment (N = 32), with mild cognitive impairment (N = 23), and PDD (N = 50), according to their score on clinical dementia rating. Multivariate regression analysis was performed considering age, education, and disease severity as covariates and mild cognitive impairment or dementia as outcome variables. Receiver operating characteristic curve analysis was carried out to derive the optimal cut-off points. Results: The cut-off point >2.5 (sensitivity = 86.96%, area under curve (AUC) = 0.88) was obtained for discriminating patients with mild cognitive impairment from those without cognitive impairment based on the total score of QDRS. The cut-off point >5 (sensitivity = 84%, AUC = 0.84) was derived for discriminating mild cognitive impairment from dementia based on the total score of QDRS. Conclusions: The results of this study showed a good discriminative validity of the QDRS for discriminating mild cognitive impairment from no cognitive impairment and dementia in patients with PD.IMPLICATIONS FOR REHABILITATION The Quick Dementia Rating System has a good discriminative validity for diagnosing mild cognitive impairment from normal cognitive function in Parkinson's disease. The Quick Dementia Rating System has a good discriminative validity for diagnosing mild cognitive impairment from dementia in Parkinson's disease. The Quick Dementia Rating System could be suggested as a routine rapid cognitive screening tool for patients with Parkinson's disease. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

2. Reliability, Validity, and Diagnostic Accuracy of Parkinson's Disease-Cognitive Rating Scale in Iranian Patients With Idiopathic Parkinson's Disease, Disability and Rehabilitation (2022)

3. Depression Is Associated With the Nonmotor Symptoms of Parkinson's Disease: A Comparative Analysis, Health Science Reports (2024)

4. Disruption of Inferior Longitudinal Fasciculus Microstructure in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies, Frontiers in Neurology (2018)

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Style	Citing Format
MLA	Mahmoudi Asl A, et al.. "Staging of Cognitive Impairment in Parkinson’S Disease: Validity of Quick Dementia Rating System." Disability and Rehabilitation, vol. 44, no. 1, 2022, pp. 44-51.
APA	Mahmoudi Asl A, Mehdizadeh M, Raeesi Roudbari P, Mehdizadeh H, Habibi SA, Niazi Khatoon J, Taghizadeh G (2022). Staging of Cognitive Impairment in Parkinson’S Disease: Validity of Quick Dementia Rating System. Disability and Rehabilitation, 44(1), 44-51.
Chicago	Mahmoudi Asl A, Mehdizadeh M, Raeesi Roudbari P, Mehdizadeh H, Habibi SA, Niazi Khatoon J, Taghizadeh G. "Staging of Cognitive Impairment in Parkinson’S Disease: Validity of Quick Dementia Rating System." Disability and Rehabilitation 44, no. 1 (2022): 44-51.
Harvard	Mahmoudi Asl A et al. (2022) 'Staging of Cognitive Impairment in Parkinson’S Disease: Validity of Quick Dementia Rating System', Disability and Rehabilitation, 44(1), pp. 44-51.
Vancouver	Mahmoudi Asl A, Mehdizadeh M, Raeesi Roudbari P, Mehdizadeh H, Habibi SA, Niazi Khatoon J, et al.. Staging of Cognitive Impairment in Parkinson’S Disease: Validity of Quick Dementia Rating System. Disability and Rehabilitation. 2022;44(1):44-51.
BibTex	@article{ author = {Mahmoudi Asl A and Mehdizadeh M and Raeesi Roudbari P and Mehdizadeh H and Habibi SA and Niazi Khatoon J and Taghizadeh G}, title = {Staging of Cognitive Impairment in Parkinson’S Disease: Validity of Quick Dementia Rating System}, journal = {Disability and Rehabilitation}, volume = {44}, number = {1}, pages = {44-51}, year = {2022} }
RIS	TY - JOUR AU - Mahmoudi Asl A AU - Mehdizadeh M AU - Raeesi Roudbari P AU - Mehdizadeh H AU - Habibi SA AU - Niazi Khatoon J AU - Taghizadeh G TI - Staging of Cognitive Impairment in Parkinson’S Disease: Validity of Quick Dementia Rating System JO - Disability and Rehabilitation VL - 44 IS - 1 SP - 44 EP - 51 PY - 2022 ER -

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