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Assessment of Dysphagia and Its Associations in Patients With Secondary Progressive Multiple Sclerosis Publisher Pubmed



Hamidi M1 ; Rezaeimanesh N1 ; Sahraian MA1 ; Naser Moghadasi A1
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Authors Affiliations
  1. 1. Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Sina Hospital, Hasan Abad Sq., Tehran, Iran

Source: Multiple Sclerosis and Related Disorders Published:2025


Abstract

In this cross-sectional study in patients with secondary progressive multiple sclerosis receiving anti-CD20 monoclonal antibodies, we assessed complaint of dysphagia and evaluated their association with sex, age, disease duration, disability severity, and disease-modifying therapies (DMTs). The validated Persian version of Dysphagia in Multiple Sclerosis (DYMUS) questionnaire was used. A total of 66 patients were included. The median DYMUS score was 1.0 [interquartile range: 0.0-2.3] and 40 (60.6%) had positive DYMUS. Only DMT showed a significant association with DYMUS score, with patients receiving reituximab exhibiting higher scores (mean estimated difference: 0.96 (±0.39), p = 0.014). Grouping patients into positive and negative DYMUS scores, no significant associations were observed (p > 0.05). © 2024 Elsevier B.V.
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