Presentation of a Residual Post-Myocardial Infarction Ventricular Septal Defect; a Literature Review Based on a Case Report Publisher Pubmed



Jafari M¹ ; Khani M¹ ; Akbari T¹ ; Farahani E^{1, 5} ; Bayat F¹ ; Bagheri A¹ ; Nasrollahizadeh A² ; Ramezani P³ ; Ebrahimi P² ; Mandegar MH⁴ Show Affiliations
Source: Journal of Cardiothoracic Surgery Published:2025

Abstract

Introduction: In the era of modern techniques for the early diagnosis and revascularization of myocardial infarction, post-myocardial infarction ventricular septal defect is rarely seen. However, this potentially fatal complication of ischemic cardiac events cannot always be detected and diagnosed in a straightforward pattern of practice. This study presents an initially delayed-presented post-infarction ventricular septal defect. Case presentation: The patient was a 58-year-old white man who presented to the cardiology clinic complaining of moderate exertional dyspnea initiated two months ago and exacerbated by the time. His medical history includes an admission three years prior, where he was diagnosed with COVID-19 pneumonia and a myocardial infarction that was complicated by a ventricular septal defect (VSD) and hemodynamic instability. This condition was managed through urgent surgical revascularization and closure of the defect. Due to his current symptoms, further cardiac investigations were planned. A transthoracic echocardiogram was recommended after detecting a grade 3/6 systolic murmur during the physical examination. The initial assessment using an apical four-chamber TTE appeared normal. However, when performing a modified view with a posterior tilt, a bulging septum was observed, leaning toward the right ventricle. This bulging contained a defect with a left-to-right shunt, identified as a residual defect in the area of the repaired patch, along with a myocardial aneurysm. Due to the inconsequential findings from the echocardiogram study, the patient was scheduled for a follow-up echocardiogram, which showed no changes after six months. Additionally, the patient underwent therapeutic management addressing chronic obstructive pulmonary disease. Conclusion: Although post-infarction ventricular septal defects are rarely seen in the revascularization era, the COVID-19 era was associated with an increase in the prevalence of this complication. It is important to be vigilant for patients who experienced an index event during that time. This potentially fatal complication can present with new issues following the initial event, such as residual defects. Comprehensive imaging studies are necessary to detect the underlying pathology. Key clinical message: Diagnosing post-infarction ventricular septal defect requires the hypervigilance and precision of the cardiologist, who examines the patient and performs the cardiac imaging. Therefore, comprehensive investigations are crucial in patients with a suspicious history of ischemic cardiac events. © The Author(s) 2025.