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The Relation Between Stressful Life Events and Breast Cancer: A Systematic Review and Meta-Analysis of Cohort Studies Publisher Pubmed



Bahri N1 ; Fathi Najafi T2 ; Homaei Shandiz F3 ; Tohidinik HR4, 5 ; Khajavi A6
Authors
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Authors Affiliations
  1. 1. Department of Midwifery, Faculty of Medicine, Social Development and Health Promotion Center, Gonabad University of Medical Sciences, Gonabad, Iran
  2. 2. Department of Midwifery, Mashhad Branch, Islamic Azad University, Mashhad, Iran
  3. 3. Department of Radiation Oncology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
  5. 5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Social Medicine, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

Source: Breast Cancer Research and Treatment Published:2019


Abstract

Purpose: Breast cancer is the most common cancer among women with high rate of mortality. This systematic review and meta-analysis was conducted to investigate the relation between stressful life events and breast cancer. Methods: We searched PubMed, Scopus, ScienceDirect, and Google scholar databases from their inception until June 2018. The keywords and phrases we used in the search were (life events AND stress AND breast cancer OR neoplasm) to identify potentially relevant cohort studies that reported relative risk estimates and confidence intervals of this association. Pooled Risk ratio and 95% confidence intervals (CIs) were calculated using random effects model. Results: Out of 168 potentially relevant publications, 11 documents met the inclusion criteria. The results showed that history of stressful life events slightly increases the risk of breast cancer [pooled Risk Ratio: 1.11 (95% CI 1.03 to 1.19)]. Conclusions: History of stressful life events could be associated with a moderate increase in the risk of breast cancer. We advise that receiving psychological and counseling services after occurrence of stressful life events of women should be taken seriously. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
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