Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Ubiquitin-Specific Proteases (Usps) in Leukemia: A Systematic Review Publisher Pubmed



Zangooie A1, 2 ; Tavoosi S3 ; Arabhosseini M4 ; Halimi A5, 6 ; Zangooie H7 ; Baghsheikhi AH8, 9 ; Rahgozar S9 ; Ahmadvand M11, 12 ; Jarrahi AM12, 13 ; Salehi Z13, 14
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
  2. 2. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
  3. 3. Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran
  4. 4. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Research Center for Social Determinants of Health, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  9. 9. Department of Cell and Molecular Biology & amp
  10. 10. Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
  11. 11. Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology, and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  13. 13. Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  14. 14. Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Cancer Published:2024


Abstract

Background: Leukemia, a type of blood cell cancer, is categorized by the type of white blood cells affected (lymphocytes or myeloid cells) and disease progression (acute or chronic). In 2020, it ranked 15th among the most diagnosed cancers and 11th in cancer-related deaths globally, with 474,519 new cases and 311,594 deaths (GLOBOCAN2020). Research into leukemia’s development mechanisms may lead to new treatments. Ubiquitin-specific proteases (USPs), a family of deubiquitinating enzymes, play critical roles in various biological processes, with both tumor-suppressive and oncogenic functions, though a comprehensive understanding is still needed. Aim: This systematic review aimed to provide a comprehensive review of how Ubiquitin-specific proteases are involved in pathogenesis of different types of leukemia. Methods: We systematically searched the MEDLINE (via PubMed), Scopus, and Web of Science databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA) to identify relevant studies focusing on the role of USPs in leukemia. Data from selected articles were extracted, synthesized, and organized to present a coherent overview of the subject matter. Results: The review highlights the crucial roles of USPs in chromosomal aberrations, cell proliferation, differentiation, apoptosis, cell cycle regulation, DNA repair, and drug resistance. USP activity significantly impacts leukemia progression, inhibition, and chemotherapy sensitivity, suggesting personalized diagnostic and therapeutic approaches. Ubiquitin-specific proteases also regulate gene expression, protein stability, complex formation, histone deubiquitination, and protein repositioning in specific leukemia cell types. Conclusion: The diagnostic, prognostic, and therapeutic implications associated with ubiquitin-specific proteases (USPs) hold significant promise and the potential to transform leukemia management, ultimately improving patient outcomes. © The Author(s) 2024.