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Advice on Assistance and Protection From the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 2. on Preventing and Treating Health Effects From Acute, Prolonged, and Repeated Nerve Agent Exposure, and the Identification of Medical Countermeasures Able to Reduce or Eliminate the Longer Term Health Effects of Nerve Agents Publisher Pubmed



Timperley CM1 ; Abdollahi M2 ; Alamri AS3 ; Baulig A4 ; Benachour D5 ; Borrett V6, 7 ; Carino FA8 ; Geist M9 ; Gonzalez D10 ; Kane W11 ; Kovarik Z12 ; Martinezalvarez R13 ; Fusaro Mourao NM14 ; Neffe S15 Show All Authors
Authors
  1. Timperley CM1
  2. Abdollahi M2
  3. Alamri AS3
  4. Baulig A4
  5. Benachour D5
  6. Borrett V6, 7
  7. Carino FA8
  8. Geist M9
  9. Gonzalez D10
  10. Kane W11
  11. Kovarik Z12
  12. Martinezalvarez R13
  13. Fusaro Mourao NM14
  14. Neffe S15
  15. Raza SK16
  16. Rubaylo V17
  17. Suarez AG18
  18. Takeuchi K19
  19. Tang C20
  20. Trifiro F21
  21. Van Straten FM22
  22. Vanninen PS23
  23. Vucinic S24
  24. Zaitsev V25, 26
  25. Zafaruzzaman M27
  26. Zina MS28
  27. Holen S29
  28. Forman JE30, 34
  29. Alwan WS31, 32
  30. Suri V33
Show Affiliations
Authors Affiliations
  1. 1. Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, United Kingdom
  2. 2. Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Saudi Basic Industries Corporation (SABIC), Riyadh, Saudi Arabia
  4. 4. Secretariat General de la Defense et de la Securite Nationale (SGDSN), Paris, France
  5. 5. LMPMP, Faculty of Technology, Ferhat Abbas University, Setif-1, Algeria
  6. 6. BAI Scientific, Melbourne, Australia
  7. 7. University of Melbourne, Melbourne, Australia
  8. 8. University of the Philippines, Quezon City, Philippines
  9. 9. BASF SE, Ludwigshafen, Germany
  10. 10. Facultad de Quimica, Universidad de la Republica, Montevideo, Uruguay
  11. 11. Monsanto Company, LA, United States
  12. 12. Institute for Medical Research and Occupational Health, Zagreb, Croatia
  13. 13. Complutense University, Madrid, Spain
  14. 14. ABIQUIM, Brazilian Chemical Industry Association, Sao Paulo, Brazil
  15. 15. Military University of Technology, Warsaw, Poland
  16. 16. Institute of Pesticides Formulation Technology (IPFT), Gurugram, Haryana, India
  17. 17. State Scientific Research Institute of Organic Chemistry and Technology (GosNIIOKhT), Moscow, Russian Federation
  18. 18. Universidad Nacional de Rosario, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Rosario, Argentina
  19. 19. National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan
  20. 20. Office for the Disposal of Japanese Abandoned Chemical Weapons, Ministry of National Defence, Beijing, China
  21. 21. Department of Industrial Chemistry, University of Bologna, Bologna, Italy
  22. 22. South African Nuclear Energy Corporation SOC Ltd., Pretoria, South Africa
  23. 23. VERIFIN, Department of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland
  24. 24. National Poison Control Centre, Military Medical Academy, Belgrade, Serbia
  25. 25. Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
  26. 26. Pontifical Catholic University of Rio de Janeiro, Brazil
  27. 27. National Engineering and Scientific Commission (NESCOM), Islamabad, Pakistan
  28. 28. Faculty of Sciences of Tunis (FST), Tunis, Tunisia
  29. 29. OPCW Scientific Advisory Board Secretary, 2011-2016, Netherlands
  30. 30. Scientific Advisory Board and Science Policy Adviser, Organisation for the Prohibition of Chemical Weapons (OPCW), The Hague, Netherlands
  31. 31. OPCW Scientific Advisory Board Secretary and Science Policy Adviser, Intern 2015-2016, Netherlands
  32. 32. Medicinal Chemistry Department, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, 3052, Victoria, Australia
  33. 33. OPCW Office of Strategy and Policy, Intern Summer 2018, Netherlands
  34. 34. The Organisation for the Prohibition of Chemical Weapons (OPCW), The Hague, Netherlands

Source: Toxicology Published:2019


Abstract

The Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) has provided advice in relation to the Chemical Weapons Convention on assistance and protection. We present the SAB's response to a request from the OPCW Director-General in 2014 for information on the best practices for preventing and treating the health effects from acute, prolonged, and repeated organophosphorus nerve agent (NA) exposure. The report summarises pre- and post-exposure treatments, and developments in decontaminants and adsorbing materials, that at the time of the advice, were available for NAs. The updated information provided could assist medics and emergency responders unfamiliar with treatment and decontamination options related to exposure to NAs. The SAB recommended that developments in research on medical countermeasures and decontaminants for NAs should be monitored by the OPCW, and used in assistance and protection training courses and workshops organised through its capacity building programmes. © 2018 Elsevier B.V.
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