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Rsfmri Based Evidence for Functional Connectivity Alterations in Adults With Developmental Stuttering Publisher



Shojaeilangari S1 ; Radman N1, 2 ; Taghizadeh ME3 ; Soltanianzadeh H1, 4, 5
Authors
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Authors Affiliations
  1. 1. School of Cognitive Science, Institute for Research in Fundamental Sciences (IPM), P.O. Box 1954851167, Tehran, Iran
  2. 2. Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Psychology, Payame Noor University, Tehran, Iran
  4. 4. CIPCE, School of Electrical and Computer Engineering, College of Engineering, Tehran University, Tehran, Iran
  5. 5. Departments of Radiology and Research Administration, Henry Ford Health System, Detroit, Michigan, United States

Source: Heliyon Published:2021


Abstract

Persistent developmental stuttering (PDS) is defined as a speech disorder mainly characterized by intermittent involuntary disruption in normal fluency, time patterning, and rhythm of speech. Although extensive functional neuroimaging studies have explored brain activation alterations in stuttering, the main affected brain regions/ networks in PDS still remain unclear. Here, using functional magnetic resonance imaging (fMRI), we investigated resting-state whole-brain functional connectivity of 15 adults who stutter (PDS group) and 15 age-matched control individuals to reveal the connectivity abnormalities associated with stuttering. We were also interested in exploring how the severity of stuttering varies across individuals to understand the compensatory mechanism of connectivity pattern in patients showing less symptoms. Our results revealed decreased connectivity of left frontal pole and left middle frontal gyrus (MidFG) with right precentral/postcentral gyrus in stuttering individuals compared with control participants, while less symptomatic PDS individuals showed greater functional connectivity between left MidFG and left caudate. Additionally, our finding indicated reduced connectivity in the PDS group between the left superior temporal gyrus (STG) and several brain regions including the right limbic lobe, right fusiform, and right cerebellum, as well as the left middle temporal gyrus (MTG). We also observed that PDS individuals with less severe symptoms had stronger connectivity between right MTG and several left hemispheric regions including inferior frontal gyrus (IFG) and STG. The connectivity between right fronto-orbital and right MTG was also negatively correlated with stuttering severity. These findings may suggest the involvement of right MTG and left MidFG in successful compensatory mechanisms in more fluent stutterers © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
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