The Efficacy and Safety of Other Cryotherapy Compounds for the Treatment of Genital Warts: A Randomized Controlled Trial Publisher Pubmed



Firooz A^{1, 2} ; Hosseini H² ; Izadi Firouzabadi L¹ ; Nassiri Kashani M¹ ; Nasrollahi SA¹ Show Affiliations
Source: Journal of Dermatological Treatment Published:2019

Abstract

Background: Cryotherapy using Wartner compound that contains a mixture of dimethyl ether (75%) and propane (25%) has been recently reported as an effective treatment for warts. The present study aimed to evaluate the safety and efficacy of Wartner in male patients with genital warts. Methods: A Phase II parallel-randomized clinical trial was performed on 16 Iranian men affected by genital warts who were referred to a dermatology clinic at Tehran University of Medical Sciences. Two genital warts of each patient were selected and randomly assigned to receive either Wartner (intervention) or liquid nitrogen (control). Results: Two weeks after the treatment, the sizes of the lesions in control and intervention groups decreased by 17.87 ± 2.14 mm2 and 15.81 ± 1.80 mm2, respectively (p =.299). Fourteen days after a single session of treatment, 81% of lesions in the control group and 50% in the Wartner group were completely eradicated, however, the difference was not statistically significant (p =.063). Conclusions: The Wartner compound is as effective as the conventional cryotherapy method for treating genital warts. It is particularly valuable when there are contraindications or no access to common treatment options. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.