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Immunosenescence and Inflamm-Ageing in Covid-19 Publisher Pubmed



Zinatizadeh MR1, 2 ; Zarandi PK1, 2 ; Ghiasi M3 ; Kooshki H4 ; Mohammadi M5 ; Amani J6 ; Rezaei N7, 8, 9
Authors
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Authors Affiliations
  1. 1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Cancer Biology Signaling Pathway Interest Group (CBSPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  4. 4. Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Applied Biotechnology Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran
  6. 6. Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  7. 7. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Ageing Research Reviews Published:2023


Abstract

The destructive effects of coronavirus disease 2019 (COVID-19) on the elderly and people with cardiovascular disease have been proven. New findings shed light on the role of aging pathways on life span and health age. New therapies that focus on aging-related pathways may positively impact the treatment of this acute respiratory infection. Using new therapies that boost the level of the immune system can support the elderly with co-morbidities against the acute form of COVID-19. This article discusses the effect of the aging immune system against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the pathways affecting this severity of infection. © 2022 Elsevier B.V.
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