Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Acetaminophen As Adjuvant to Risperidone in Chronic Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial



Arabzadeh S1 ; Zeinoddini A1 ; Mostafavi SA1 ; Hamedi M1 ; Ehyaii A1 ; Ghaleiha A2 ; Zeinoddini A1 ; Akhondzadeh S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Behavioral Disorders and Substance Abuse Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Source: Iranian Journal of Psychiatry Published:2018

Abstract

Objective: Although the pathogenesis of schizophrenia is still uncertain, a variety of predisposing mechanisms have been implicated including inflammatory cascades. The present study was conducted to investigate the effectiveness of acetaminophen as a cyclooxygenase inhibitor in treating patients with schizophrenia. Method: A double-blind clinical trial was performed on 52 patients with chronic schizophrenia. Patients received risperidone (up to 6 mg/day) plus either acetaminophen (975mg/day) or placebo. Psychotic symptoms were assessed by the Positive and Negative Syndrome Scale (PANSS) at the onset of the trial, and at 2, 4, 6, and 8 weeks post therapy. Results: Compared to the placebo group, the acetaminophen group showed no significant difference in any subtypes of PANSS. Moreover, the side effect profiles of the 2treatment regimens were not significantly different. Conclusion: Acetaminophen adjuvant to risperidone showed no significant effect in ameliorating symptoms of schizophrenia. © 2018, Tehran University of Medical Sciences.
Related Docs
View other Related Docs
1. The Effects of Pioglitazone Adjuvant Therapy on Negative Symptoms of Patients With Chronic Schizophrenia: A Double-Blind and Placebo-Controlled Trial, Human Psychopharmacology (2016)
2. Celecoxib Adjunctive Therapy for Acute Bipolar Mania: A Randomized, Double-Blind, Placebo-Controlled Trial, Bipolar Disorders (2015)
3. Duloxetine Add-On to Risperidone for Treatment of Negative Symptoms in Patients With Stable Schizophrenia: Randomized Double-Blind Placebo-Controlled Study, Pharmacopsychiatry (2016)
4. Resveratrol Adjunct Therapy for Negative Symptoms in Patients With Stable Schizophrenia: A Double-Blind, Randomized Placebo-Controlled Trial, International Journal of Neuropsychopharmacology (2020)
5. Simvastatin Adjunct Therapy for Negative Symptoms of Schizophrenia: A Randomized Double-Blind Placebo-Controlled Trial, International Clinical Psychopharmacology (2017)
6. Cilostazol Adjunctive Therapy in Treatment of Negative Symptoms in Chronic Schizophrenia: Randomized, Double-Blind, Placebo-Controlled Study, Human Psychopharmacology (2017)
7. Celecoxib for the Treatment of Mild-To-Moderate Depression Due to Acute Brucellosis: A Double-Blind, Placebo-Controlled, Randomized Trial, Journal of Clinical Pharmacy and Therapeutics (2015)
8. A Randomized, Double-Blind Placebo-Controlled Trial on Effectiveness and Safety of Celecoxib Adjunctive Therapy in Adolescents With Acute Bipolar Mania, Journal of Child and Adolescent Psychopharmacology (2017)
Experts (# of related papers)
View all Related Experts
Shahin Akhondzadeh Basti (29)
Farzin Rezaei (8)
Other Related Docs
9. L-Theanine Adjunct to Risperidone in the Treatment of Chronic Schizophrenia Inpatients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Psychopharmacology (2023)
10. Celecoxib Versus Diclofenac in Mild to Moderate Depression Management Among Breast Cancer Patients: A Double-Blind, Placebo-Controlled, Randomized Trial, Annals of Pharmacotherapy (2015)
11. Vortioxetine As Adjunctive Therapy to Risperidone for Treatment of Patients With Chronic Schizophrenia: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial, Journal of Psychopharmacology (2020)
12. Therapeutic Effects of Minocycline on Mild-To-Moderate Depression in Hiv Patients: A Double-Blind, Placebo-Controlled, Randomized Trial, International Clinical Psychopharmacology (2016)
13. Efficacy and Safety of Adjunctive Therapy With Fingolimod in Patients With Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Schizophrenia Research (2023)
14. Adjuvant Palmitoylethanolamide Therapy With Risperidone Improves Negative Symptoms in Patients With Schizophrenia: A Randomized, Double-Blinded, Placebo-Controlled Trial, Psychiatry Research (2022)
15. Citicoline Combination Therapy for Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial, Clinical Neuropharmacology (2017)
16. Risperidone Combination Therapy With Adalimumab for Treatment of Chronic Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, International Clinical Psychopharmacology (2022)
17. Minocycline As Adjunctive Treatment to Risperidone in Children With Autistic Disorder: A Randomized, Double-Blind Placebo-Controlled Trial, Journal of Child and Adolescent Psychopharmacology (2016)
18. Comparison of Saffron Versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial, Pharmacopsychiatry (2017)
19. Effect of Memantine Combination Therapy on Symptoms in Patients With Moderate-To-Severe Depressive Disorder: Randomized, Double-Blind, Placebo-Controlled Study, Journal of Clinical Pharmacy and Therapeutics (2017)
20. Citicoline (Cdp-Choline) Add-On Therapy to Risperidone for Treatment of Negative Symptoms in Patients With Stable Schizophrenia: A Double-Blind, Randomized Placebo-Controlled Trial, Human Psychopharmacology (2018)
21. L-Carnosine As an Add-On to Risperidone for Treatment of Negative Symptoms in Patients With Stable Schizophrenia: A Double-Blind, Randomized Placebo-Controlled Trial, Psychiatry Research (2018)
22. Pioglitazone Adjunctive Therapy for Depressive Episode of Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial, Depression and Anxiety (2015)
23. Efficacy and Safety of Celecoxib Monotherapy for Mild to Moderate Depression in Patients With Colorectal Cancer: A Randomized Double-Blind, Placebo Controlled Trial, Psychiatry Research (2017)
24. Riluzole Combination Therapy for Moderate-To-Severe Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Psychiatric Research (2016)
25. Herbal Medicine in the Treatment of Schizophrenia: A Review, Journal of Medicinal Plants (2018)
26. Pregnenolone As an Adjunct to Risperidone for Treatment of Women With Schizophrenia: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Journal of Psychiatric Research (2017)
27. Review of Clinical Studies Targeting Inflammatory Pathways for Individuals With Autism, Frontiers in Psychiatry (2019)
28. Effect of Adjunctive Celecoxib on Bdnf in Manic Patients Undergoing Electroconvulsive Therapy: A Randomized Double Blind Controlled Trial, Pharmacopsychiatry (2015)
29. Minocycline Combination Therapy With Fluvoxamine in Moderate-To-Severe Obsessive–Compulsive Disorder: A Placebo-Controlled, Double-Blind, Randomized Trial, Psychiatry and Clinical Neurosciences (2016)
30. Cytokine Alterations in Schizophrenia: An Updated Review, Frontiers in Psychiatry (2019)
31. Effect of Valerian in Preventing Neuropsychiatric Adverse Effects of Efavirenz in Hiv-Positive Patients: A Pilot Randomized, Placebo-Controlled Clinical Trial, Annals of Pharmacotherapy (2017)
32. Looking for Autoimmune Psychosis: A Preliminary Report From Iran, Iranian Journal of Psychiatry and Behavioral Sciences (2021)
33. Efficacy of Spironolactone As an Adjunctive Therapy to Risperidone to Improve Symptoms of Schizophrenia: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial, Iranian Journal of Psychiatry (2022)