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The Influence of Polymer Type and Concentration on the Metoprolol Mass Transfer in Extended-Release Tablet of Metoprolol Succinate Publisher



Khadivparsi P1 ; Rafieetehrani M2 ; Dorkoosh F3 ; Darabad JB4 ; Azizpour H1 ; Rezamandi N5 ; Larki N1
Authors
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Authors Affiliations
  1. 1. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  2. 2. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medical Biomaterial Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Shimi Pajohan Sabze Nikan, Tehran, Iran
  5. 5. Department of Civil, Chemical, Environmental, and Material Engineering (DICAM), Alma Mater Studiorum - University of Bologna, Bologna, Italy

Source: Journal of Chemical and Petroleum Engineering Published:2023


Abstract

Metoprolol has been widely used for controlling high blood pressure, preventing myocardial reinfarction, setting rate changes, setting heart rhythm, treatment of chronic angina, and preventing excessive bleeding during surgery. The purpose of this research is the formulation and manufacture of extended-release tablets of metoprolol succinate that conform to all the in vitro physicochemical US Pharmacopoeia national formulary (USP32). For preparing the tablets, the hydrophilic HPMC(K100M) polymer was used in the direct compression method. The release of metoprolol in phosphate buffer having pH=6.8 (USP32) was measured by HPLC. Also, using experimental correlation of diffusivity in a buffer medium and Gurney-Lurie charts during tablet enlargement with time, diffusion coefficients of drug and partition coefficients were obtained at different time steps. The rate of drug release depends on the type, viscosity, and polymer concentration. Drug release results over 20 hours for polymers of HPMC(K100M), HPMC(K4M), HPMC(K15M), polyethylene oxide, ethyl cellulose, and Eudragit (RL100) were investigated and compared. The results demonstrated that HPMC(K100M) met the standards of USP32 very well and was superior over the other polymers tested. © Parissa Khadiv-Parsi, MortezaRafiee-Tehrani, Farid Dorkoosh, Jaber Babaee Darabad, Hedayat Azizpour, Nariman Rezamandi, Nadia Larki.