Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Oncologic and Pregnancy Outcomes of a Fertility Sparing Treatment in Endometrial Cancer: A Single Center Experience Publisher



Mousavi A1 ; Amirpoor R1 ; Akhavan S1 ; Sheikh Hassani S2 ; Zamani N2 ; Rezayof E3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Gynecology Oncology, Valie-e-Asr Hospital, Imam Khomeini Hospital, Tehran University of Medical Sciences, Keshavarz Blvd, Tehran, Iran
  2. 2. Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Vali-e-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Indian Journal of Gynecologic Oncology Published:2024


Abstract

Purpose: There has also been an increase in number of women with endometrial carcinoma (EC) in their reproductive years who wish to retain their fertility. We aimed to report the treatment results in EC patients underwent fertility-sparing treatment in Iran. Methods: This is a case-series study conducted on women diagnosed with stage IA, grade 1 EC. Treatment was initiated using either megestrol acetate, medroxyprogesterone acetate (MPA) or MPA and metformin. Patients showing partial remission or disease persistence continued their hormone therapy and those showing disease persistence after 12 months or showing disease progression underwent the standard surgical intervention of hysterectomy and bilateral salpingo-oophorectomy. Bariatric surgery was also performed to improve overall prognosis in those indicated. Results: Our study included 22 subjects, with a mean age of 32.82 ± 5.46 years. Treatment results included complete remission in 10 (45.5%), relative remission in 2 (9.1%), persistence in 4 (18.2%) and disease progression in 6 (27.3%) subjects. 5 (22.7%) subjects had a spontaneous pregnancy and 13 (59.1%) underwent embryo cryopreservation. At 1-year timepoint, 8 (36.3%) subjects had a live birth, including 5 (22.7%) with a spontaneous pregnancy and 3 (13.6%) through a uterine surrogate. Side effects observed from hormonal therapy included weight gain (9.1%) and abnormal blood sugar and liver function tests (4.5%). Conclusion: Overall, a conservative treatment approach to patients with EC aiming to preserve their fertility can be safe and have acceptable outcomes in terms of oncologic response as well as pregnancy results. © The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024.
Related Docs
1. Tubal Ligation and Endometrial Cancer Risk: A Global Systematic Review and Meta-Analysis, BMC Cancer (2019)
Experts (# of related papers)
Nafiseh Saedi (1)