Uncovering Antidepressant Prescription Patterns: A Three-Year Analysis of Outpatient Trends Publisher Pubmed

Summary: ADs rising in Iran? Study (n=3.5M) shows SSRIs dominant (63.7%), women/older lead. Research urges monitoring for elderly. Mood med trends? #Antidepressants #MentalHealth

Karami H¹ ; Mehrizi R¹ ; Effatpanah M² ; Rivandi A³ ; Daroudi R⁴ ; Armand N⁵ ; Ghamkhar L¹
Source: BMC Psychiatry Published:2025

Abstract

Background: Antidepressants (ADs) are prescribed for various conditions, including neurological and rheumatoid diseases. This study aims to analyze ADs prescribing trends in Iranian outpatients over three years, with a focus on age, sex, and ADs class. Methods: A retrospective cohort study was conducted using prescription data from the Iranian Health Insurance Organization (IHIO) between March 2021 and March 2024. The dataset included 8,924,431 prescriptions from 3,524,273 patients who received at least one ADs. ADs were classified into four groups: tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and atypical ADs. The data were processed via the cross-industry standard process for data mining and analyzed using a multivariate logistic regression model. Results: SSRIs were the most commonly prescribed class, accounting for 63.71% of prescriptions, with sertraline being the most common drug (24.65%). Females accounted for 66.11% of the patient population. ADs prescriptions increased with age, and females were more likely to receive TCAs and SNRIs than males, who had higher rates of atypical ADs use. Conclusions: This study revealed a notable increase in ADs prescriptions in Iran, particularly among women and older individuals. Continued monitoring of ADs prescription is crucial for optimizing outcomes, especially for vulnerable groups such as elderly individuals. © The Author(s) 2025.