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Risk of Obstructive Pulmonary Diseases and Occupational Exposure to Pesticides: A Systematic Review and Meta-Analysis Publisher Pubmed



Pourhassan B1 ; Meysamie A2 ; Alizadeh S3 ; Habibian A4 ; Beigzadeh Z5
Authors
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Authors Affiliations
  1. 1. Department of Occupational Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Social Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Iran
  4. 4. Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran

Source: Public Health Published:2019


Abstract

Objective: This meta-analysis study was performed to examine the relationship between occupational exposure to pesticides and the risk of obstructive pulmonary diseases such as chronic obstructive pulmonary disease (COPD) and chronic bronchitis. Study design: This is a systematic review and meta-analysis study. Methods: PubMed and Scopus databases were searched for English-language publications. Eight cohort studies and one case–control study were included in the pooled analysis. Results: These studies had a total of 101,353 participants from eleven different countries and were published between 2006 and 2018. The heterogeneity among the studies was high (P < 0.001, I2 = 68.7%). In a random-effects model meta-analysis, a pooled odds ratio (OR) analysis showed that there was a direct relationship between occupational exposure to the pesticides and obstructive pulmonary diseases (OR = 1.33, 95% confidence interval [CI]: 1.21–1.47). A positive significant relationship was also observed between exposure to the pesticides and risk of chronic bronchitis (OR = 1.27, 95% CI: 1.23–1.31). Also, there was a significant relationship between occupational exposure to the pesticides and an increased risk of COPD (OR = 1.44, 95% CI: 1.14–1.81). No evidence of publication bias was found among the studies according to the results of the Egger's test (P of bias = 0.157). Conclusions: Findings of this study show that occupational exposure to pesticides can be associated with an increased risk of obstructive lung diseases including chronic bronchitis and COPD. © 2019 The Royal Society for Public Health
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1. Pesticides: An Update of Human Exposure and Toxicity, Archives of Toxicology (2017)
2. Burden of Obstructive Lung Disease Study in Iran: First Report of the Prevalence and Risk Factors of Copd in Five Provinces, Lung India (2019)
3. Global Prevalence of Chronic Obstructive Pulmonary Disease: Systematic Review and Meta-Analysis; [Prevalence Mondiale De La Bronchopneumopathie Chronique Obstructive: Analyse Systematique Et Meta-Analyse], Eastern Mediterranean Health Journal (2019)
4. Burden of Obstructive Lung Disease in Iran: Prevalence and Risk Factors for Copd in North of Iran, International Journal of Preventive Medicine (2020)
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