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Tacrine Publisher



Khaleseh F1 ; Haghiaminjan H2 ; Samadi M3
Authors

Source: Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 Published:2023


Abstract

In the early 1950s, tacrine was used experimentally to reverse cholinergic coma in animals. In 1993, the US Food and Drug Administration approved tacrine for the treatment of mild to moderate Alzheimer's disease. Tacrine causes reversible acetylcholinesterase inhibition in the brain, and thereby boosts the level of acetylcholine to sustain memory. In addition, tacrine blocks sodium and potassium channels. At a therapeutic dose, tacrine causes liver toxicity. Tacrine-induced hepatotoxicity is due to oxidative stress. Treatment rests with use of atropine, antioxidants, and other symptomatic measures. Tacrine is no longer indicated for Alzheimer's treatment. © 2024 Elsevier Inc. All rights reserved.
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