Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Preparation, Optimization and in Vitro Characterization of Fluticasoneloaded Mixed Micelles Based on Stearic Acid-G-Chitosan As a Pulmonary Delivery System Publisher Pubmed



S Tasharoie SHIMA ; Sn Ostad Seyed NASSER ; M Amini MOHSEN ; R Sabourian REYHANEH ; K Gilani KAMBIZ
Authors

Source: Recent Advances in Drug Delivery and Formulation Published:2024


Abstract

Purpose: The primary objective of this study was to optimize formulation variables and investigate the in vitro characteristics of fluticasone propionate (FP)-loaded mixed polymeric micelles, which were composed of depolymerized chitosan-stearic acid copolymer (DC-SA) in combination with either tocopheryl polyethylene glycol succinate or dipalmitoylphosphatidylcholine for pulmonary drug delivery. Methods: A D-optimal design was employed for the optimization procedure, considering lipid/ polymer ratio, polymer concentration, drug/ polymer ratio, and lipid type as independent variables. Dependent variables included particle size, polydispersion index, zeta potential, drug encapsulation efficiency, and loading efficiency of the polymeric micelles. Additionally, the nebulization efficacy and cell viability of the optimal FP-loaded DC-SA micellar formulations were evaluated. Results: The mixed polymeric micelles were successfully prepared with properties falling within the desired ranges, resulting in four optimized formulations. The release of FP from the optimal systems exhibited a sustained release profile over 72 hours, with 70% of the drug still retained within the core of the micelles. The nebulization efficiency of these optimal formulations reached up to 63%, and the fine particle fraction (FPF) ranged from 41% to 48%. Cellular viability assays demonstrated that FP-loaded DC-SA polymeric micelles exhibited lower cytotoxicity than the free drug but were slightly more cytotoxic than empty mixed micelles. Conclusion: In conclusion, this study suggests that DC-SA/ lipid mixed micelles have the potential to serve as effective carriers for nebulizing poorly soluble FP. © 2024 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Poly(Lactic Acid)/Poly(Lactic-Co-Glycolic Acid) Particulate Carriers for Pulmonary Drug Delivery, Journal of Pharmaceutical Investigation (2019)
2. Application of Chitosan in Oral Drug Delivery, Functional Chitosan: Drug Delivery and Biomedical Applications (2020)
3. Synthesis of Depo-Medrol–Chitosan Hydrogel As New Drug Slow-Release Appliance and Investigation of Release Kinetics by High-Performance Liquid Chromatography, Biomedical Chromatography (2016)
Experts (# of related papers)
View all Related Experts
Rassoul Dinarvand (3)
Alireza Vatanara (3)
Other Related Docs
4. Targeted Ph- and Redox-Responsive Aus/Micelles With Low Cmc for Highly Efficient Sonodynamic Therapy of Metastatic Breast Cancer, Biomaterials Advances (2024)
5. Diazepam Loaded Solid Lipid Nanoparticles: In Vitro and in Vivo Evaluations, Advanced Pharmaceutical Bulletin (2022)
6. Pluronic F127 Polymeric Micelles for Co-Delivery of Paclitaxel and Lapatinib Against Metastatic Breast Cancer: Preparation, Optimization and in Vitro Evaluation, Pharmaceutical Development and Technology (2015)
7. Design and Characterization of Mesalamine Loaded Nanoparticles for Controlled Delivery System, Nanomedicine Research Journal (2016)
8. Optimization of a Dry Powder Inhaler of Ciprofloxacin-Loaded Polymeric Nanomicelles by Spray Drying Process, Pharmaceutical Development and Technology (2019)
9. Preparation, Statistical Optimization and in Vitro Characterization of Solid Lipid Nanoparticles As a Potential Vehicle for Transdermal Delivery of Tramadol Hydrochloride As a Hydrophilic Compound, Nanomedicine Research Journal (2020)
10. Ph-Responsive Chitosan-Adorned Niosome Nanocarriers for Co-Delivery of Drugs for Breast Cancer Therapy, ACS Applied Nano Materials (2022)
11. Recent Progress in the Application of Plant-Based Colloidal Drug Delivery Systems in the Pharmaceutical Sciences, Advances in Colloid and Interface Science (2022)
12. Synthesis and Characterization of Chitosan/Polyvinylpyrrolidone Coated Nanoporous Γ-Alumina As a Ph-Sensitive Carrier for Controlled Release of Quercetin, International Journal of Biological Macromolecules (2021)
13. Aerosol Delivery of Ferulic Acid-Loaded Nanostructured Lipid Carriers: A Promising Treatment Approach Against the Respiratory Disorders, Physiology and Pharmacology (Iran) (2017)
14. Nanocarriers Usage for Drug Delivery in Cancer Therapy, International Journal of Cancer Management (2016)
15. Optimization of Docetaxel Loading Conditions in Liposomes: Proposing Potential Products for Metastatic Breast Carcinoma Chemotherapy, Scientific Reports (2020)
16. Preparation and Characterization of Self Nano-Emulsifying Drug Delivery System (Snedds) for Oral Delivery of Heparin Using Hydrophobic Complexation by Cationic Polymer of Β-Cyclodextrin, Drug Development and Industrial Pharmacy (2017)
17. Biological and Thermodynamic Stabilization of Lipid-Based Delivery Systems Through Natural Biopolymers; Controlled Release and Molecular Dynamics Simulations, Critical Reviews in Food Science and Nutrition (2023)
18. Inhaled Sildenafil Nanocomposites: Lung Accumulation and Pulmonary Pharmacokinetics*, Pharmaceutical Development and Technology (2016)
19. Nimodipine-Loaded Pluronic® Block Copolymer Micelles: Preparation, Characterization, In-Vitro and In-Vivo Studies, Iranian Journal of Pharmaceutical Research (2016)
20. Application of Response Surface Method for Preparation, Optimization, and Characterization of Nicotinamide Loaded Solid Lipid Nanoparticles, Advanced Pharmaceutical Bulletin (2018)